Wang Chih-Lu, Wu Yu-Tsun, Liu Chieh-An, Kuo Ho-Chang, Yang Kuender D
Division of Pediatric Immunology, Chang-Gung Children's Hospital at Kaohsiung, 123 Ta-Pei Road, Niau-Sung, Kaohsiung 833, Taiwan.
Pediatr Infect Dis J. 2005 Nov;24(11):998-1004. doi: 10.1097/01.inf.0000183786.70519.fa.
Kawasaki disease is an acute multisystem vasculitic syndrome of unknown etiology occurring mostly in infants and children younger than 5 years of age. In developed countries, Kawasaki disease is currently the leading cause of acquired heart diseases in children. However, it is still a mysterious disease. In this article, we reviewed and summarized from the aspects based on infection agents, host immune dysregulation and genetic background intended to establish a feasible infection-immunogenetic pathogenesis for this mysterious disease and also provided the rational strategy to explore optimal treatment of this disease.
川崎病是一种病因不明的急性多系统血管炎性综合征，主要发生于5岁以下的婴幼儿。在发达国家，川崎病是目前儿童后天性心脏病的主要病因。然而，它仍然是一种神秘的疾病。在本文中，我们从感染因子、宿主免疫失调和遗传背景等方面进行了综述和总结，旨在为这种神秘疾病建立一种可行的感染-免疫遗传发病机制，并为探索该病的最佳治疗方法提供合理策略。
