钠钾ATP酶在器官型培养中心脏组织外植体生长中的调节作用。

Regulatory role of Na,K-ATPase in the growth of heart tissue explants in organotypic culture.

作者信息

Lopatina E V, Penniyainen V A, Zaika A A

机构信息

V. A. Almazov Institute of Cardiology, Russian Ministry of Health, St. Petersburg.

出版信息

Bull Exp Biol Med. 2005 Aug;140(2):184-6. doi: 10.1007/s10517-005-0440-x.

DOI:10.1007/s10517-005-0440-x

PMID:16282996

Abstract

We studied the effects of ouabain, norepinephrine, and acetylcholine on the growth of heart tissue explants from 10-12-old chicken embryos in an organotypic culture. Ouabain, norepinephrine, and acetylcholine stimulated the growth of explants. Our results suggest that trophic function of acetylcholine and norepinephrine is associated with regulation of Na,K-ATPase activity as a signal transducer.

摘要

我们在器官型培养中研究了哇巴因、去甲肾上腺素和乙酰胆碱对10 - 12日龄鸡胚心脏组织外植体生长的影响。哇巴因、去甲肾上腺素和乙酰胆碱刺激了外植体的生长。我们的结果表明，乙酰胆碱和去甲肾上腺素的营养功能与作为信号转导器的钠钾ATP酶活性的调节有关。