Penniyaynen V A, Kipenko A V, Lopatina E V, Krylov B V
Laboratory of Excitable Membrane Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2013 Feb;154(4):419-20. doi: 10.1007/s10517-013-1965-z.
Organotypic culture was used to study the effects of glycoside ouabain and its aglycone ouaba-genin on the growth of skin explants from 10-12-day chicken embryos. The tested agents demonstrated dose-dependent inhibition of skin growth. The effective concentrations imply that ouabain and ouabagenin mediate their inhibitory effect on the skin growth via interaction with α1-isoform of Na(+),K(+)-ATPase that plays mostly the role of ionic pump.
采用器官型培养法研究了糖苷哇巴因及其苷元哇巴因对10 - 12日龄鸡胚皮肤外植体生长的影响。受试药物表现出对皮肤生长的剂量依赖性抑制作用。有效浓度表明，哇巴因和哇巴因苷元通过与主要起离子泵作用的Na(+)，K(+)-ATP酶α1亚型相互作用，介导其对皮肤生长的抑制作用。
