Perricone R, Pasetto N, De Carolis C, Vaquero E, Piccione E, Baschieri L, Fontana L
Cattedra di Immunologia Clinica, II University of Rome Tor Vergata, Italy.
Clin Exp Immunol. 1992 Jul;89(1):154-7. doi: 10.1111/j.1365-2249.1992.tb06895.x.
Human ovarian preovulatory follicular fluids (FF) from 10 women were analysed for their complement contents. Functionally active complement was detected in all the fluids studied in amounts similar to those present in normal human serum. Pooled FF was challenged by seminal plasma in order to determine whether seminal plasma could activate FF complement, the pattern of such an activation and the possible consequences on the reproductive function. FF complement activation occurred during the incubation with seminal plasma with features including alternative pathway activation, factor B and C3 conversion and reduction in total haemolytic complement, as well as an inhibition by seminal plasma of the FF complement response to a new activating challenge. Possible consequences for fertilization, implantation of a fertilized ovum and local defence mechanisms against viruses and bacteria are discussed.
对10名女性的人卵巢排卵前卵泡液（FF）进行了补体含量分析。在所有研究的卵泡液中均检测到具有功能活性的补体，其含量与正常人血清中的含量相似。为了确定精浆是否能激活卵泡液补体、这种激活的模式以及对生殖功能可能产生的影响，将混合的卵泡液与精浆进行了反应。卵泡液补体激活发生在与精浆孵育期间，其特征包括替代途径激活、因子B和C3转化以及总溶血补体减少，同时精浆还抑制了卵泡液补体对新激活刺激的反应。文中讨论了对受精、受精卵着床以及针对病毒和细菌的局部防御机制可能产生的影响。
