Potter B J, Elias E, Fayers P M, Jones E A
Digestion. 1978;18(5-6):371-83. doi: 10.1159/000198223.
CH50 and the concentrations of C3, C4, C1 INH and factor B have been measured in sera from 34 control subjects and 178 patients with various hepatobiliary diseases, including primary biliary cirrhosis (PBC), chronic active hepatitis (CAH), cryptogenic cirrhosis (CC), alcoholic liver disease (ALD), Wilson's disease (WD), large duct biliary obstruction (LDBO) and viral hepatitis (VH). CH50 was decreased in CAH and CC. C3 was increased in PBC, LDBO and VH and decreased in CAH and CC. C4 was decreased in PBC, CAH, ALD and WD. C1 INH was increased in PBC, CAH, ALD, LDBO and VH. Factor B was increased in LDBO and VH and decreased in CC. In none of the patient groups was the mean C4 level increased or the mean C1 INH level decreased. All 5 indices of serum complement were lower in ascitic than nonascitic patients. Data on serum complement were similar in HBsAg positive and negative VH. Discriminant analysis facilitated separation of all the patient groups on the basis of complement data, except PBC and VA. Analysis of data using a within-group correlation matrix revealed a significant negative correlation between C4, the most discriminating variable of serum complement in CAH, and gamma-globulin concentration in CAH. The possible contribution of factors such as activation of complement, impaired hepatic synthesis of complement components, an acute phase response and cholestasis to altered serum complement profiles in different hepatobiliary diseases is discussed.
已对34名对照受试者和178名患有各种肝胆疾病的患者的血清进行了CH50以及C3、C4、C1抑制物（C1 INH）和B因子浓度的检测，这些肝胆疾病包括原发性胆汁性肝硬化（PBC）、慢性活动性肝炎（CAH）、隐源性肝硬化（CC）、酒精性肝病（ALD）、威尔逊病（WD）、大胆管胆道梗阻（LDBO）和病毒性肝炎（VH）。CAH和CC患者的CH50降低。PBC、LDBO和VH患者的C3升高，CAH和CC患者的C3降低。PBC、CAH、ALD和WD患者的C4降低。PBC、CAH、ALD、LDBO和VH患者的C1 INH升高。LDBO和VH患者的B因子升高，CC患者的B因子降低。在所有患者组中，C4平均水平均未升高，C1 INH平均水平也未降低。腹水患者的所有5项血清补体指标均低于非腹水患者。HBsAg阳性和阴性的VH患者的血清补体数据相似。判别分析有助于根据补体数据区分所有患者组，但PBC和VA除外。使用组内相关矩阵对数据进行分析显示，CAH中血清补体最具鉴别性的变量C4与CAH中的γ-球蛋白浓度之间存在显著负相关。本文讨论了补体激活、补体成分肝脏合成受损、急性期反应和胆汁淤积等因素对不同肝胆疾病血清补体谱改变的可能影响。
