Srikrishna Anuradha, Sitalakshmi S, Devi Shanthala, Damodar Prema, Varghese Jessy, Suresh John, Mathew Thresiamma
Department of Clinical Pathology, St John's Medical College Hospital, Bangalore.
Indian J Pathol Microbiol. 2004 Apr;47(2):174-7.
Antiphospholipid antibodies (APA) have aroused multispeciality interests. In our study of 200 cases worked up for APA, we have used a few simple coagulation tests to detect lupus anticoagulant (LA) and ELISA to detect anticardiolipin antibodies. The positivity rate for LA among cases with recurrent pregnancy loss was 4.16% and for aCL 20.8%. The positivity rate for LA in patients with venous thrombosis was 6.2%, in arterial thrombosis was 7.14% and in SLE patients was 58.3%. In conclusion APAs are to be looked for in cases of recurrent pregnancy loss, thrombosis in people < 45 years of age without risk factors and SLE patients to assess the thrombotic risk and to decide on anti coagulant therapy for further management.
抗磷脂抗体（APA）已引起多个专业领域的关注。在我们对200例进行APA检查的病例研究中，我们使用了一些简单的凝血试验来检测狼疮抗凝物（LA），并使用酶联免疫吸附测定（ELISA）来检测抗心磷脂抗体。复发性流产病例中LA的阳性率为4.16%，抗心磷脂抗体（aCL）的阳性率为20.8%。静脉血栓形成患者中LA的阳性率为6.2%，动脉血栓形成患者中为7.14%，系统性红斑狼疮（SLE）患者中为58.3%。总之，对于复发性流产病例、45岁以下无危险因素的血栓形成患者以及SLE患者，应检测APA以评估血栓形成风险，并决定进一步治疗的抗凝方案。
