Krishna Smriti Murali, James Susan, Kattoor Jayashree, Balaram Prabha
Department of Cancer Research, Regional Cancer Centre, Medical College PO, Trivandrum, Kerala.
Indian J Pathol Microbiol. 2004 Apr;47(2):181-5.
Nasopharyngeal carcinoma (NPC) is a rare malignancy world-wide. It shows an increasing trend in the southern parts of India. Genetic alterations brought about by environmental factors, HPV and EBV are thought to be crucial for NPC carcinogenesis. This study reports for the first time the incidence of HPV infection in NPC in Southern India. Detection of HPV was carried out in 36 NPC and 10 adenoid lesions by immunohistochemical analysis. 38.8% of NPC were positive for HPV with higher positivity in WHO Type I and WHO Type II cancers. One among 10 adenoid lesions also showed presence of HPV. The patients belonged to low socio-economic status and had exposure to either tobacco or alcohol alone or in combination or kitchen smoke.
鼻咽癌（NPC）在全球范围内是一种罕见的恶性肿瘤。在印度南部，其发病率呈上升趋势。环境因素、人乳头瘤病毒（HPV）和爱泼斯坦-巴尔病毒（EBV）引起的基因改变被认为对鼻咽癌的致癌作用至关重要。本研究首次报告了印度南部鼻咽癌中HPV感染的发生率。通过免疫组化分析对36例鼻咽癌和10例腺样体病变进行了HPV检测。38.8%的鼻咽癌HPV呈阳性，其中WHO I型和WHO II型癌症的阳性率更高。10例腺样体病变中有1例也显示存在HPV。这些患者社会经济地位较低，单独或联合接触过烟草、酒精或厨房烟雾。
