Ouyang F, Perry M J, Venners S A, Chen C, Wang B, Yang F, Fang Z, Zang T, Wang L, Xu X, Wang X
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
Occup Environ Med. 2005 Dec;62(12):878-84. doi: 10.1136/oem.2005.020248.
Although dichlorodiphenyl trichloroethane (DDT) exposure is known to affect human endocrine function, few previous studies have investigated the effects of DDT exposure on age at menarche or menstrual cycle length.
A cross sectional study was conducted to study the effects of DDT exposure on age at menarche and menstrual cycle length among 466 newly married, nulliparous female Chinese textile workers aged 20-34 years enrolled between 1996 and 1998. Serum was analysed for DDT and its major metabolites. Multivariate linear regression was used to estimate DDT exposure effects on age at menarche and multivariate logistic regression was used to estimate DDT exposure effects on odds of experiencing short or long cycles.
Relative to those in the lowest DDT quartile, the adjusted mean age at menarche was younger in those in the fourth quartile (-1.11 years). Modeled as a continuous variable, a 10 ng/g increase in serum DDT concentration was associated with an adjusted reduction in age at menarche of 0.20 years. Relative to those in the lowest DDT quartile, odds of any short cycle (<21 days) in the previous year were higher for those in the fourth quartile (odds ratio = 2.78; 95% CI 1.07 to 7.14). There were no associations between serum DDT concentrations and odds of experiencing a long cycle (>40 days).
Results suggest that DDT exposure was associated with earlier age at menarche and increased risk of experiencing a shortened menstrual cycle.
尽管已知接触二氯二苯三氯乙烷（DDT）会影响人体内分泌功能，但以往很少有研究调查DDT暴露对初潮年龄或月经周期长度的影响。
开展了一项横断面研究，以研究1996年至1998年间招募的466名年龄在20 - 34岁之间的新婚未育中国纺织女工中，DDT暴露对初潮年龄和月经周期长度的影响。分析血清中的DDT及其主要代谢产物。采用多元线性回归估计DDT暴露对初潮年龄的影响，采用多元逻辑回归估计DDT暴露对月经周期过短或过长几率的影响。
与DDT四分位数最低组相比，四分位数最高组的初潮校正平均年龄更小（-1.11岁）。将血清DDT浓度作为连续变量建模，血清DDT浓度每增加10 ng/g，初潮年龄校正后降低0.20岁。与DDT四分位数最低组相比，四分位数最高组在前一年出现任何短周期（<21天）的几率更高（优势比 = 2.78；95%置信区间1.07至7.14）。血清DDT浓度与月经周期过长（>40天）的几率之间无关联。
结果表明，DDT暴露与初潮年龄提前以及月经周期缩短风险增加有关。
