Perry Melissa J, Ouyang Fengxiu, Korrick Susan, Venners Scott A, Altshul Larisa, Xu Xiping, Wang Xiaobin
Department of Environmental Health, Harvard School of Public Health, Room 1413, Building 1, 665 Huntington Avenue, Boston, MA 02115, USA.
Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2433-8. doi: 10.1158/1055-9965.EPI-05-0174.
Basic health indicators, such as body mass index (BMI), have been associated with serum 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT/DDE) levels; however, both positive and inverse associations of BMI with serum DDT/DDE have been reported. Given the association of BMI with a number of outcomes, it may confound studies of DDT/DDE-associated health effects. We investigated the relationship of BMI with serum DDT/DDE accounting for other determinants of exposure among women with relatively recent environmental exposures to DDT.
Serum DDT/DDE was analyzed in 466 nonsmoking, nulliparous women recruited from Anhui province in China between 1996 and 1998 as part of a reproductive health study of textile workers. The women in the sample were born between 1963 and 1977, 8 to 21 years before China's 1984 DDT ban. We used multivariate linear regression to investigate associations of BMI, age, and birth year with serum DDT/DDE.
Mean (SD) serum total DDT concentration was 32 ng/g (17.8 ng/g). Birth year showed an inverse relationship with serum DDT independent of age. Despite limited variability in BMI, there was a consistent inverse relationship between BMI and serum DDT. Specifically, each kg/m(2) increase in BMI was associated with a -1.34 ng/g (95% confidence interval, -2.12 to -0.56 ng/g) decrease in serum total DDT.
There were high total DDT levels in this sample of nulliparous Chinese women relative to Western populations, birth year was more strongly associated with serum DDT than age, and BMI was inversely related to serum DDT in this study.
基本健康指标，如体重指数（BMI），已被证明与血清1,1,1-三氯-2,2-双（对氯苯基）乙烷/1,1-二氯-2,2-双（对氯苯基）乙烯（滴滴涕/滴滴伊）水平相关；然而，BMI与血清滴滴涕/滴滴伊之间的正相关和负相关均有报道。鉴于BMI与多种结果相关，它可能会混淆对滴滴涕/滴滴伊相关健康影响的研究。我们在近期有过滴滴涕环境暴露的女性中，研究了BMI与血清滴滴涕/滴滴伊的关系，并考虑了其他暴露决定因素。
作为对纺织工人生殖健康研究的一部分，于1996年至1998年从中国安徽省招募了466名不吸烟、未生育的女性，分析她们血清中的滴滴涕/滴滴伊。样本中的女性出生于1963年至1977年，在中国1984年禁止使用滴滴涕之前的8至21年。我们使用多元线性回归来研究BMI、年龄和出生年份与血清滴滴涕/滴滴伊之间的关联。
血清总滴滴涕浓度的均值（标准差）为32 ng/g（17.8 ng/g）。出生年份与血清滴滴涕呈负相关，且不受年龄影响。尽管BMI的变异性有限，但BMI与血清滴滴涕之间存在一致的负相关关系。具体而言，BMI每增加1 kg/m²，血清总滴滴涕浓度降低-1.34 ng/g（95%置信区间，-2.12至-0.56 ng/g）。
相对于西方人群，该未生育中国女性样本中的总滴滴涕水平较高，出生年份比年龄与血清滴滴涕的关联更强，且在本研究中BMI与血清滴滴涕呈负相关。
