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本文引用的文献

1
Glucuronoxylomannan, a microbial compound, regulates expression of costimulatory molecules and production of cytokines in macrophages.葡糖醛酸木聚糖甘露聚糖是一种微生物化合物，可调节巨噬细胞中共刺激分子的表达和细胞因子的产生。
J Infect Dis. 2005 Jan 1;191(1):127-37. doi: 10.1086/426511. Epub 2004 Dec 2.
2
Effects of the capsular polysaccharides of Cryptococcus neoformans on phagocyte migration and inflammatory mediators.新型隐球菌荚膜多糖对吞噬细胞迁移和炎症介质的影响。
Curr Med Chem. 2004 Jan;11(2):253-66. doi: 10.2174/0929867043456188.
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Organ plasma volume of normal unanesthetized mice.正常未麻醉小鼠的器官血浆容量。
Proc Soc Exp Biol Med. 1955 Mar;88(3):323-5. doi: 10.3181/00379727-88-21577.
4
Differences in outcome of the interaction between Cryptococcus neoformans glucuronoxylomannan and human monocytes and neutrophils.新型隐球菌葡糖醛酸木聚糖甘露聚糖与人类单核细胞和中性粒细胞相互作用的结果差异。
Eur J Immunol. 2003 Apr;33(4):1041-51. doi: 10.1002/eji.200323388.
5
CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans.补体受体3（CR3，CD11b/CD18）和补体受体4（CR4，CD11c/CD18）参与不依赖补体的抗体介导的新型隐球菌吞噬作用。
Immunity. 2002 Jun;16(6):791-802. doi: 10.1016/s1074-7613(02)00328-x.
6
In vivo clearance of glucuronoxylomannan, the major capsular polysaccharide of Cryptococcus neoformans: a critical role for tissue macrophages.新型隐球菌主要荚膜多糖葡糖醛酸木聚糖甘露聚糖的体内清除：组织巨噬细胞的关键作用
J Infect Dis. 2001 Aug 15;184(4):479-87. doi: 10.1086/322787. Epub 2001 Jul 13.
7
Toll-like receptor 4 mediates intracellular signaling without TNF-alpha release in response to Cryptococcus neoformans polysaccharide capsule.Toll样受体4介导细胞内信号传导，在响应新型隐球菌多糖荚膜时不释放肿瘤坏死因子-α。
J Immunol. 2001 Apr 1;166(7):4620-6. doi: 10.4049/jimmunol.166.7.4620.
8
Divergent response to LPS and bacteria in CD14-deficient murine macrophages.CD14缺陷型小鼠巨噬细胞对脂多糖和细菌的不同反应。
J Immunol. 2000 Oct 15;165(8):4272-80. doi: 10.4049/jimmunol.165.8.4272.
9
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.Toll样受体2（TLR2）和Toll样受体4（TLR4）在识别革兰氏阴性菌和革兰氏阳性菌细胞壁成分中的不同作用
Immunity. 1999 Oct;11(4):443-51. doi: 10.1016/s1074-7613(00)80119-3.
10
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product.前沿：Toll样受体4（TLR4）缺陷小鼠对脂多糖反应低下：TLR4作为Lps基因产物的证据
J Immunol. 1999 Apr 1;162(7):3749-52.

体内受体介导的新型隐球菌荚膜多糖清除作用

Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo.

作者信息

Yauch Lauren E, Mansour Michael K, Levitz Stuart M

机构信息

Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.

出版信息

Infect Immun. 2005 Dec;73(12):8429-32. doi: 10.1128/IAI.73.12.8429-8432.2005.

DOI:10.1128/IAI.73.12.8429-8432.2005
PMID:16299344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1307074/
Abstract

Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant mice, none of the receptors was absolutely required for serum clearance or hepatosplenic accumulation.

摘要

新型隐球菌荚膜葡糖醛酸木聚糖甘露聚糖（GXM）在隐球菌病期间脱落并被巨噬细胞摄取。研究了假定的GXM受体CD14、CD18、Toll样受体2（TLR2）和TLR4在受体缺陷小鼠中从血清清除GXM以及在肝脏和脾脏中沉积的作用。虽然在突变小鼠中观察到GXM重新分布动力学的改变，但血清清除或肝脾积累并非绝对需要任何一种受体。