Radhakrishnan Raghu, Suhas Setty, Kumar Rekha V, Krishnanand Geeta, Srinivasan Rangarajan, Rao Nirmala N
Manipal College of Dental Sciences, Manipal, India.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Dec;100(6):725-31. doi: 10.1016/j.tripleo.2005.03.028. Epub 2005 Oct 14.
A 7-year-old boy with a positive history of vertical HIV transmission presented with a painful swelling over the left upper jaw of 20 days' duration. A provisional diagnosis of non-Hodgkin's lymphoma or embryonal rhabdomyosarcoma was made. Fine-needle aspiration cytology findings were inconclusive, and incisional biopsy tissue on routine stains gave an impression of small round cell tumor with plasmacytoid features. A series of histochemical stains and immunohistochemical studies was carried out to differentiate and characterize this tumor. The salient immunostaining was negativity with all routine small round cell tumor markers and positivity with CD138 and lambda light chain restriction. The heterogeneous presentation of plasmablastic lymphoma as a variant of diffuse large B-cell lymphoma and its histogenesis is documented. Potential pitfalls and differential characterization of AIDS-plasmablastic lymphoma from other closely related tumors are addressed. The importance of excluding other common pediatric small round cell tumors by immunohistochemistry is highlighted. To the best of our knowledge, this is the first report of this entity in a vertically transmitted HIV-positive child.
一名有垂直HIV传播阳性史的7岁男孩，左上颌出现持续20天的疼痛性肿胀。初步诊断为非霍奇金淋巴瘤或胚胎性横纹肌肉瘤。细针穿刺细胞学检查结果不明确，常规染色的切开活检组织显示为具有浆细胞样特征的小圆形细胞肿瘤。进行了一系列组织化学染色和免疫组织化学研究以鉴别和表征该肿瘤。显著的免疫染色结果是所有常规小圆形细胞肿瘤标志物均为阴性，而CD138和λ轻链限制性阳性。记录了浆母细胞性淋巴瘤作为弥漫性大B细胞淋巴瘤变体的异质性表现及其组织发生。探讨了艾滋病相关浆母细胞性淋巴瘤与其他密切相关肿瘤的潜在陷阱和鉴别特征。强调了通过免疫组织化学排除其他常见儿童小圆形细胞肿瘤的重要性。据我们所知，这是垂直传播的HIV阳性儿童中该实体的首例报告。
