Raez Luis E, Fein Steven, Podack Eckhard R
Epidemiology and Public Health, Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, FL 33136, USA.
Clin Med Res. 2005 Nov;3(4):221-8. doi: 10.3121/cmr.3.4.221.
Recent insights into anti-tumor immunotherapy have led to a wave of clinical trials involving immunotherapy for lung cancer. Vaccines have evolved from nonspecific immune stimulants, like Bacillus Calmette-Guerin (BCG), to much more specific and potent strategies, some of which generate active immune responses against tumor-associated antigens. Understanding the mechanisms of anti-tumor immunity and identifying target antigens will likely improve these therapeutic strategies and provide them with a niche in the future of lung cancer therapy.
最近对抗肿瘤免疫疗法的深入了解引发了一波涉及肺癌免疫疗法的临床试验浪潮。疫苗已从非特异性免疫刺激剂,如卡介苗(BCG),发展到更为特异和有效的策略,其中一些策略可产生针对肿瘤相关抗原的主动免疫反应。了解抗肿瘤免疫机制并确定靶抗原可能会改善这些治疗策略,并使其在肺癌治疗的未来占据一席之地。