Jarvik Lissy F, La Rue Asenath, Gokhman Izabella, Harrison Tracy, Holt Lori, Steh Bill, Harker Judith, Larson Scott, Yaralian Pauline, Matsuyama Steven, Rasgon Natalie, Geschwind Daniel, Freimer Nelson, Jimenez Elvira, Schaeffer Jeffrey
University of California, Los Angeles (UCLA), Department of Psychiatry and Biobehavioral Sciences and Neuropsychiatric Institute and Hospital, Los Angeles, California 90095-1759, USA.
J Geriatr Psychiatry Neurol. 2005 Dec;18(4):187-91. doi: 10.1177/0891988705281862.
The objective of this pilot study on a convenience sample of 25 offspring of Alzheimer patients (mean age 61.5 +/- 8.8 years; range, 50-82) was the early detection of neurocognitive decline. This preliminary report appears to be the first one dealing with 20-year follow-up of neurocognitive data of Alzheimer's disease (AD) children. Digit symbol (Wechsler Adult Intelligence Scale) was the only of 11 neurocognitive measures with a significant decline. And that decline between first and last testing (mean = 19.98 +/- 0.30 years) was on raw scores, not scaled scores. Neither parents' age at onset of AD nor autopsy confirmation or offspring APOE-e4 status influenced neurocognitive results. More robust data than currently available are needed to confirm the findings of this first pilot study and to determine both the trajectory of neurocognitive decline in AD and the risks of developing AD faced by children whose parent had the disease.
这项针对25名阿尔茨海默病患者后代（平均年龄61.5±8.8岁；范围为50-82岁）的便利样本的初步研究，其目的是早期检测神经认知衰退。这份初步报告似乎是第一份涉及对阿尔茨海默病（AD）患儿神经认知数据进行20年随访的报告。数字符号（韦氏成人智力量表）是11项神经认知测量指标中唯一出现显著下降的指标。首次和末次测试之间（平均=19.98±0.30年）的下降是基于原始分数，而非量表分数。父母患AD的发病年龄、尸检确认情况或后代的APOE-e4状态均未影响神经认知结果。需要比目前可得的数据更有力的数据来证实这项首次初步研究的结果，并确定AD中神经认知衰退的轨迹以及父母患有该病的儿童患AD的风险。
