Miyake K, Miyake T, Kayazawa F
Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan.
Ophthalmology. 1992 Jun;99(6):906-10. doi: 10.1016/s0161-6420(92)31875-5.
The purpose of this study is to examine the changes of blood-aqueous barrier function in cases of central or branch retinal vein occlusion.
In addition to fluorophotometry of the aqueous humor and posterior vitreous, the authors used a method that quantifies protein in the aqueous (aqueous flare) by measuring the intensity of scattered laser light.
Aqueous and posterior vitreous fluorescein concentrations and aqueous flare were significantly higher than in unaffected fellow eyes or eyes of visually normal age-matched controls both in central and branch retinal vein occlusions. They also were significantly higher in eyes with central vein occlusion than in those with branch vein occlusion. Among those eyes with central vein occlusion, aqueous and posterior vitreous fluorescein concentrations and aqueous flare were significantly higher in the hemorrhagic than in the venous stasis type of disease. Among eyes with branch vein occlusion, cases at the acute stage showed significantly higher amounts of aqueous and posterior vitreous fluorescein concentrations and aqueous flare than did those with chronic occlusion.
The authors believe that increased amounts mainly reflect blood-ocular barrier disruption. Not only the blood-retinal barrier but also the blood-aqueous barrier disruption is a common sequela in the disorder.
本研究的目的是检查视网膜中央静脉阻塞或分支静脉阻塞病例中血-房水屏障功能的变化。
除了对房水和玻璃体后段进行荧光光度测定外，作者还采用了一种通过测量散射激光光强度来量化房水中蛋白质（房水闪光）的方法。
在视网膜中央静脉阻塞和分支静脉阻塞中，房水和玻璃体后段的荧光素浓度以及房水闪光均显著高于未受影响的对侧眼或年龄匹配的视力正常对照者的眼睛。在中央静脉阻塞的眼中，其也显著高于分支静脉阻塞的眼。在那些中央静脉阻塞的眼中，出血型疾病的房水和玻璃体后段荧光素浓度以及房水闪光显著高于静脉淤滞型。在分支静脉阻塞的眼中，急性期病例的房水和玻璃体后段荧光素浓度以及房水闪光量显著高于慢性阻塞病例。
作者认为增加的量主要反映血-眼屏障破坏。血-视网膜屏障以及血-房水屏障破坏都是该疾病常见的后遗症。
