Hashimura S, Kohno Y, Gohbara H, Nakagawa T, Shimizu M, Niiya H, Takeda Y, Hiraki Y
Department of Radiology, Okayama University School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1992 Apr 25;52(4):503-4.
We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using 99mTc-DTPA-Galactosyl-Human-Serum-Albumin (99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, 99mTc-GSA was intravenously administered (170 micrograms/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that 99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion.
我们使用99mTc-DTPA-半乳糖基-人血清白蛋白（99mTc-GSA）对缺血再灌注诱导的大鼠肝损伤进行了定量评估。夹闭左叶血管5分钟、10分钟或45分钟，随后再灌注15分钟。然后，向大鼠静脉注射99mTc-GSA（170微克/千克体重）。对心脏和肝脏的测量曲线进行二室分析以获得清除参数。缺血组（夹闭10分钟和45分钟）与对照组之间观察到显著差异。这些结果表明，99mTc-GSA可用于评估缺血再灌注所致的肝损伤。
