自身抗体阴性的甲状腺功能正常的Graves眼病
Euthyroid Graves' ophthalmopathy with negative autoantibodies.
作者信息
Cakir Mehtap
机构信息
Division of Endocrinology and Metabolism, Selcuk University, Meram School of Medicine, Konyo, Turkey.
出版信息
J Natl Med Assoc. 2005 Nov;97(11):1547-9.
Abstract
Graves' disease is an autoimmune-based hyperthyroidism in which a number of different antibodies directed against thyroid tissue plays a role. Graves' ophthalmopathy is thought to be a consequence of this autoimmune basis and occurs in some patients with Graves' disease. On occasional cases, the disease may present only with ophthalmopathy without hyperthyroidism. A 32-year-old woman with euthyroid Graves' ophthalmopathy and negative thyroid autoantibodies, including TSH receptor antibody, is presented here.
摘要
格雷夫斯病是一种基于自身免疫的甲状腺功能亢进症，其中多种针对甲状腺组织的不同抗体发挥作用。格雷夫斯眼病被认为是这种自身免疫基础的结果，发生在一些格雷夫斯病患者身上。在少数情况下，该病可能仅表现为眼病而无甲状腺功能亢进。本文介绍了一名32岁患有甲状腺功能正常的格雷夫斯眼病且甲状腺自身抗体（包括促甲状腺激素受体抗体）阴性的女性。
相似文献
1
Euthyroid Graves' ophthalmopathy with negative autoantibodies.
J Natl Med Assoc. 2005 Nov;97(11):1547-9.
2
Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy.
BMC Ophthalmol. 2018 Jan 12;18(1):5. doi: 10.1186/s12886-018-0672-y.
3
Clinical Implications of Immunoglobulin G4 to Graves' Ophthalmopathy.
Thyroid. 2017 Sep;27(9):1185-1193. doi: 10.1089/thy.2017.0126.
4
Childhood Graves' ophthalmopathy: results of a European questionnaire study.
Eur J Endocrinol. 2005 Oct;153(4):515-21. doi: 10.1530/eje.1.01991.
5
Cloning and characterization of the novel thyroid and eye muscle shared protein G2s: autoantibodies against G2s are closely associated with ophthalmopathy in patients with Graves' hyperthyroidism.
J Clin Endocrinol Metab. 2000 Apr;85(4):1641-7. doi: 10.1210/jcem.85.4.6553.
6
Unilateral optic neuropathy as the initial manifestation of euthyroid Graves' disease.
Intern Med. 2009;48(22):1993-4. doi: 10.2169/internalmedicine.48.2372. Epub 2009 Nov 16.
7
Correlation of orbital muscle changes evaluated by magnetic resonance imaging and thyroid-stimulating antibody in patients with Graves' ophthalmopathy.
Acta Endocrinol (Copenh). 1993 Sep;129(3):213-9. doi: 10.1530/acta.0.1290213.
8
Advances in treatment of active, moderate-to-severe Graves' ophthalmopathy.
Lancet Diabetes Endocrinol. 2017 Feb;5(2):134-142. doi: 10.1016/S2213-8587(16)30046-8. Epub 2016 Jun 23.
9
TSH receptor antibody titers measured with a third-generation assay did not reflect the activity of Graves' ophthalmopathy in untreated Japanese Graves' disease patients.
Endocr J. 2016;63(2):151-7. doi: 10.1507/endocrj.EJ15-0137. Epub 2015 Nov 18.
10
Sustained control of Graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe Graves' orbitopathy.
Thyroid. 2011 Sep;21(9):951-6. doi: 10.1089/thy.2011.0039. Epub 2011 Aug 11.
引用本文的文献
1
A Case of Euthyroid Graves' Ophthalmopathy With Negative Thyroid Antibodies.
Cureus. 2024 Nov 12;16(11):e73527. doi: 10.7759/cureus.73527. eCollection 2024 Nov.
2
Identification of Graves' ophthalmology by laser-induced breakdown spectroscopy combined with machine learning method.
Front Optoelectron. 2021 Sep;14(3):321-328. doi: 10.1007/s12200-020-0978-2. Epub 2020 Apr 14.
3
A systematic review of euthyroid Graves' disease (Review).
Exp Ther Med. 2021 Nov;22(5):1346. doi: 10.3892/etm.2021.10781. Epub 2021 Sep 22.
4
Exophthalmos and multinodular goitre, an unusual combination.
Endocrinol Diabetes Metab Case Rep. 2019 May 3;2019. doi: 10.1530/EDM-18-0138.
5
A Case of Euthyroid Graves' Ophthalmopathy in a Patient Sero-Negative for TSH Receptor Autoantibody.
Case Rep Endocrinol. 2018 Jun 13;2018:1707959. doi: 10.1155/2018/1707959. eCollection 2018.
6
Clinical course of thyroid function and thyroid associated-ophthalmopathy in patients with euthyroid Graves' disease.
Clin Ophthalmol. 2018 Apr 19;12:739-746. doi: 10.2147/OPTH.S158967. eCollection 2018.
7
Thyroid-associated orbitopathy in patients with thyroid carcinoma: A case report of 5 cases.
Medicine (Baltimore). 2017 Nov;96(47):e8768. doi: 10.1097/MD.0000000000008768.
8
Thyroid antibody-negative euthyroid Graves' ophthalmopathy.
Endocrinol Diabetes Metab Case Rep. 2016;2016:160008. doi: 10.1530/EDM-16-0008. Epub 2016 Jun 2.
9
Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients.
Eye (Lond). 2012 Sep;26(9):1263-9. doi: 10.1038/eye.2012.132. Epub 2012 Jun 29.
10
Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves' disease.
Clin Exp Immunol. 2006 Jul;145(1):56-62. doi: 10.1111/j.1365-2249.2006.03110.x.
本文引用的文献
1
Thyroid autoantibody profiles in ophthalmic dominant and thyroid dominant Graves' disease differ and suggest ophthalmopathy is a multiantigenic disease.
Clin Endocrinol (Oxf). 2004 May;60(5):600-7. doi: 10.1111/j.1365-2265.2004.02033.x.
2
Current perspective on the pathogenesis of Graves' disease and ophthalmopathy.
Endocr Rev. 2003 Dec;24(6):802-35. doi: 10.1210/er.2002-0020.
3
Clinical significance of classification of Graves' disease according to the characteristics of TSH receptor antibodies.
Korean J Intern Med. 2001 Sep;16(3):187-200. doi: 10.3904/kjim.2001.16.3.187.
4
Association of the HLA-DRB1*0301 and HLA-DQA1*0501 alleles with Graves' disease in a population representing the gene contribution from several ethnic backgrounds.
Thyroid. 2001 Jan;11(1):31-5. doi: 10.1089/10507250150500630.
5
Graves' ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels: prevalence, natural history, and thyrotropin receptor antibody levels.
Thyroid. 2000 Dec;10(12):1093-100. doi: 10.1089/thy.2000.10.1093.
6
Thyroid-stimulating antibody is related to Graves' ophthalmopathy, but thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves' disease.
Thyroid. 2000 Sep;10(9):809-13. doi: 10.1089/thy.2000.10.809.
7
The prevalence and clinical significance of blocking thyrotropin receptor antibodies in untreated hyperthyroid Graves' disease.
Thyroid. 2000 Jul;10(7):579-86. doi: 10.1089/thy.2000.10.579.
8
Association of thyrotrophin receptor antibodies with the clinical features of Graves' ophthalmopathy.
Clin Endocrinol (Oxf). 2000 Mar;52(3):267-71. doi: 10.1046/j.1365-2265.2000.00959.x.
9
The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves' disease identifies a group at markedly increased risk of ophthalmopathy.
Thyroid. 1999 Dec;9(12):1175-80. doi: 10.1089/thy.1999.9.1175.
10
Second generation assay for thyrotropin receptor antibodies has superior diagnostic sensitivity for Graves' disease.
J Clin Endocrinol Metab. 1999 Jan;84(1):90-7. doi: 10.1210/jcem.84.1.5415.
Zotero 插件