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一例甲状腺自身抗体阴性的甲状腺功能正常的Graves眼病病例。

A Case of Euthyroid Graves' Ophthalmopathy With Negative Thyroid Antibodies.

作者信息

Abu Helwa Rashid S, Subeh Hiyam H, Katreddy Venkata, Ahmed Amir I

机构信息

General Practice, Emirates Health Services, Sharjah, ARE.

Endocrinology, American Hospital Dubai, Dubai, ARE.

出版信息

Cureus. 2024 Nov 12;16(11):e73527. doi: 10.7759/cureus.73527. eCollection 2024 Nov.

DOI:10.7759/cureus.73527
PMID:39677157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11638395/
Abstract

Grave's ophthalmopathy is a prevalent complication of Grave's disease. In this case report, we present a case of an 84-year-old female patient with no symptoms of hyperthyroidism except that of Grave's ophthalmopathy. The patient's thyroid profile was normal, and both thyroid receptor antibodies and thyroid-stimulating immunoglobulins were negative. MRI showed thickening of the medial and inferior recti muscles in both eyes. With the absence of masses on MRI, a diagnosis of Grave's ophthalmopathy was highly suspicious. Regular monitoring was done for a year, and the patient remained euthyroid with negative antibodies throughout. The patient was managed symptomatically with the addition of methylprednisolone. No surgical intervention was done.

摘要

格雷夫斯眼病是格雷夫斯病的一种常见并发症。在本病例报告中,我们介绍了一名84岁女性患者,除了格雷夫斯眼病外没有甲状腺功能亢进的症状。患者的甲状腺功能指标正常,甲状腺受体抗体和甲状腺刺激免疫球蛋白均为阴性。MRI显示双眼内直肌和下直肌增厚。由于MRI上没有肿块,格雷夫斯眼病的诊断高度可疑。进行了一年的定期监测,患者始终甲状腺功能正常且抗体阴性。患者接受了甲基强的松龙的对症治疗。未进行手术干预。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/11638395/5bf652aeb073/cureus-0016-00000073527-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/11638395/53904935493c/cureus-0016-00000073527-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/11638395/5bf652aeb073/cureus-0016-00000073527-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/11638395/53904935493c/cureus-0016-00000073527-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7707/11638395/5bf652aeb073/cureus-0016-00000073527-i02.jpg

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本文引用的文献

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A systematic review of euthyroid Graves' disease (Review).正常甲状腺功能的格雷夫斯病的系统评价(综述)
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Management of Graves Thyroidal and Extrathyroidal Disease: An Update.格雷夫斯甲状腺和甲状腺外疾病的管理:更新。
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Graves' ophthalmopathy: epidemiology and natural history.格雷夫斯眼病:流行病学与自然史
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Graves' ophthalmopathy.格雷夫斯眼病。
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Euthyroid and primarily hypothyroid patients develop milder and significantly more asymmetrical Graves ophthalmopathy.甲状腺功能正常和原发性甲状腺功能减退的患者会出现症状较轻且明显更不对称的格雷夫斯眼病。
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