猿猴病毒40特异性RNA的转录后选择
Posttranscriptional selection of simian virus 40-specific RNA.
作者信息
Khoury G, Howley P, Nathans D, Martin M
出版信息
J Virol. 1975 Feb;15(2):433-7. doi: 10.1128/JVI.15.2.433-437.1975.
Abstract
Analysis of the viral-specific RNA in simian virus 40(SV40)-infected monkey kidney cells indicated the extensive transcription of both DNA strands. These symmetrically transcribed sequences were localized in the nucleus of infected cells, whereas only the "true" early and late SV40 transcripts were found in the cytoplasm. These results suggest that selective posttranscriptional degradation and/or transport occurs after transcription of the viral DNA. On the basis of hybridization experiments with cytoplasmic RNA and the separated strands of the SV40 Hin fragments, the early SV40 region appears to include all of Hin fragments A, H, I, and B (48% of the genome), whereas the late region is represented in Hin fragments C, D, E, K, F, J, and G (52% of the genome).
摘要
对感染猿猴病毒40（SV40）的猴肾细胞中的病毒特异性RNA进行分析表明，两条DNA链均发生了广泛转录。这些对称转录的序列定位于受感染细胞的细胞核中，而在细胞质中仅发现了“真正的”SV40早期和晚期转录本。这些结果表明，病毒DNA转录后发生了选择性的转录后降解和/或转运。根据对细胞质RNA与SV40 Hin片段的分离链进行的杂交实验，SV40早期区域似乎包括所有Hin片段A、H、I和B（占基因组的48%），而晚期区域则存在于Hin片段C、D、E、K、F、J和G中（占基因组的52%）。
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