小鼠视网膜中的血管生成：一个用于实验操作的模型系统。
Angiogenesis in the mouse retina: a model system for experimental manipulation.
作者信息
Uemura Akiyoshi, Kusuhara Sentaro, Katsuta Hideto, Nishikawa Shin-Ichi
机构信息
Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, 2-2-3 Minatojima Minamimachi, Kobe 650-0047, Japan.
出版信息
Exp Cell Res. 2006 Mar 10;312(5):676-83. doi: 10.1016/j.yexcr.2005.10.030. Epub 2005 Dec 6.
The vascular system of the mouse retina provides a useful model for analyzing the molecular and cellular mechanisms regulating angiogenesis because (1) hierarchical vascular networks are newly formed only after birth, (2) the cellular components involved in angiogenesis are well characterized, and (3) all the processes are accessible for monitoring and manipulation. In this article, we present an overview of our current understanding of the process of retinal angiogenesis and describe a number of methodologies applicable to experimental manipulation of the retinal vascular system.
小鼠视网膜的血管系统为分析调节血管生成的分子和细胞机制提供了一个有用的模型，因为：（1）分级血管网络仅在出生后才新形成；（2）参与血管生成的细胞成分已得到充分表征；（3）所有过程都便于进行监测和操作。在本文中，我们概述了目前对视网膜血管生成过程的理解，并描述了一些适用于视网膜血管系统实验操作的方法。
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