Holmdahl R, Goldschmidt T J, Kleinau S, Kvick C, Jonsson R
Department of Medical and Physiological Chemistry, Uppsala University, Sweden.
Immunology. 1992 Jun;76(2):197-202.
Adjuvant arthritis in rats is usually induced by injection of mycobacterium tubercle cell walls suspended in various adjuvant oils such as Freund's incomplete adjuvant (FIA) or pristane. We have recently shown that injection of adjuvant oils without inclusion of mycobacterium tubercle cell walls triggers arthritis [oil adjuvant-induced arthritis (OIA)] in the DA rat strain. The OIA is a genetically restricted disease since only DA rats are susceptible while Lewis, DA-fostered Lewis and F1 (Lew x DA) rats are relatively resistant. Activated alpha beta T cells infiltrate the affected joints of adjuvant oil-injected DA rats and treatment with monoclonal antibodies to the alpha beta T-cell receptor abrogates development of arthritis. These findings show that alpha beta T-cell activation is a critical event in the development of OIA.
大鼠佐剂性关节炎通常通过注射悬浮于各种佐剂油（如弗氏不完全佐剂（FIA）或角鲨烯）中的结核分枝杆菌细胞壁来诱发。我们最近发现，注射不含结核分枝杆菌细胞壁的佐剂油会在DA大鼠品系中引发关节炎[油佐剂诱导的关节炎（OIA）]。OIA是一种遗传受限疾病，因为只有DA大鼠易感，而刘易斯大鼠、DA寄养的刘易斯大鼠和F1（刘易斯×DA）大鼠相对有抗性。活化的αβT细胞浸润注射佐剂油的DA大鼠的受累关节，用抗αβT细胞受体单克隆抗体治疗可消除关节炎的发展。这些发现表明，αβT细胞活化是OIA发展中的关键事件。
