佐剂性多关节炎。五、由N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺诱导，细菌肽聚糖的最小肽亚基。
Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D-isoglutamine, the smallest peptide subunit of bacterial peptidoglycan.
作者信息
Chang Y H, Pearson C M, Chedid L
出版信息
J Exp Med. 1981 Apr 1;153(4):1021-6. doi: 10.1084/jem.153.4.1021.
Abstract
N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar to that induced by Freund's complete adjuvant when injected in the form of an oil emulsion. An oil emulsion of its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed to induce the disease.
摘要
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（MDP）是一种明显无免疫原性的细菌肽聚糖衍生小肽，当以油乳剂形式注射时，发现它能在大鼠中诱发一种类似于弗氏完全佐剂诱发的多关节炎。其异构体N-乙酰胞壁酰-L-丙氨酰-L-异谷氨酰胺的油乳剂，与MDP不同，没有免疫刺激活性，不能诱发该病。
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