Kleinfeld J, Ellis P P
Division of Ophthalmology, University of Colorado Medical Center, Denver, Colorado 80220.
Appl Microbiol. 1967 Nov;15(6):1296-8. doi: 10.1128/am.15.6.1296-1298.1967.
The effect of various topical anesthetics and their preservatives on the growth of Pseudomonas aeruginosa, Staphyloccoccus albus, and Candida albicans was investigated. The topical anesthetics were proparacaine HCl, tetracaine HCl, cocaine HCl, and benoxinate HCl. The preservatives were chlorobutanol and butyl p-hydroxybenzoate. Proparacaine inhibited C. albicans but not P. aeruginosa or S. albus. All three test organisms were inhibited to varying degrees by tetracaine, benoxinate, cocaine, chlorobutanol, and butyl p-hydroxybenzoate.
研究了各种局部麻醉剂及其防腐剂对铜绿假单胞菌、白色葡萄球菌和白色念珠菌生长的影响。局部麻醉剂为盐酸丙美卡因、盐酸丁卡因、盐酸可卡因和盐酸奥布卡因。防腐剂为三氯叔丁醇和对羟基苯甲酸丁酯。丙美卡因抑制白色念珠菌，但不抑制铜绿假单胞菌或白色葡萄球菌。丁卡因、奥布卡因、可卡因、三氯叔丁醇和对羟基苯甲酸丁酯对所有三种受试微生物均有不同程度的抑制作用。
