Zenilman J M, Reichart C A, Neumann T M, Hook E W
Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Antimicrob Agents Chemother. 1991 Jun;35(6):1228-9. doi: 10.1128/AAC.35.6.1228.
We evaluated 72 clinical Neisseria gonorrhoeae isolates for in vitro susceptibility to cocaine hydrochloride and its metabolite benzoylecgonine and to penicillin, tetracycline, erythromycin, ceftriaxone, and ofloxacin. Although there was a wide range of susceptibilities to the antimicrobial agents, cocaine and its major metabolite, benzoylecgonine, had no demonstrable antigonococcal activity. Cocaine use is frequently associated with outbreaks of sexually transmitted disease. We hypothesized that the dramatically decreasing incidence of gonorrhea over the past 15 years may be in part due to pharmacological effects of cocaine. However, since cocaine and its metabolite have no in vitro antigonococcal activity, this hypothesis is unlikely.
我们评估了72株临床分离的淋病奈瑟菌对盐酸可卡因及其代谢产物苯甲酰爱康宁，以及对青霉素、四环素、红霉素、头孢曲松和氧氟沙星的体外敏感性。尽管这些抗菌药物的敏感性范围很广，但可卡因及其主要代谢产物苯甲酰爱康宁没有可证明的抗淋球菌活性。使用可卡因常常与性传播疾病的暴发有关。我们推测，在过去15年中淋病发病率急剧下降可能部分归因于可卡因的药理作用。然而，由于可卡因及其代谢产物没有体外抗淋球菌活性，这一推测不太可能成立。
