Sklerov Jason, Levine Barry, Moore Karla A, King Theodore, Fowler David
Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, 1413 Research Blvd., Rockville, Maryland 20850, USA.
J Anal Toxicol. 2005 Nov-Dec;29(8):838-41. doi: 10.1093/jat/29.8.838.
A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic tryptamines is presented. No anatomic cause of death was found at autopsy. Toxicologic analysis of the heart blood identified N,N-dimethyltryptamine (0.02 mg/L), 5-methoxy-N,N-dimethyltryptamine (1.88 mg/L), tetrahydroharmine (0.38 mg/L), harmaline (0.07 mg/L), and harmine (0.17 mg/L). All substances were extracted by a single-step n-butyl chloride extraction following alkalinization with borate buffer. Detection and quantitation was performed using liquid chromatography-electrospray mass spectrometry. The medical examiner ruled that the cause of death was hallucinogenic amine intoxication, and the manner of death was undetermined.
本文报告一例25岁白人男性病例，该患者在服用含有β-咔啉和致幻色胺的草药提取物后次日早晨被发现死亡。尸检未发现解剖学上的死因。心脏血液的毒理学分析鉴定出N,N-二甲基色胺（0.02毫克/升）、5-甲氧基-N,N-二甲基色胺（1.88毫克/升）、四氢骆驼蓬碱（0.38毫克/升）、骆驼蓬灵（0.07毫克/升）和骆驼蓬碱（0.17毫克/升）。所有物质在用硼酸盐缓冲液碱化后通过一步正丁基氯萃取法提取。使用液相色谱-电喷雾质谱法进行检测和定量。法医裁定死因是致幻胺中毒，死亡方式无法确定。
