Toledo Rafael, Monteagudo Carlos, Espert Ana, Fried Bernard, Esteban J Guillermo, Marcilla Antonio
Departamento de Parasitología, Facultad de Farmacia, Universidad de Valencia, Av. Vicente Andrés Estellés s/n, 46100 Burjassot-Valencia, Spain.
Exp Parasitol. 2006 Mar;112(3):164-71. doi: 10.1016/j.exppara.2005.11.003. Epub 2005 Dec 13.
The histopathological changes induced by Echinostoma caproni (Trematoda: Echinostomatidae) in a high (golden hamster) and a low compatible host (rat) were compared at 15 and 30 days post-infection. Infection of rats was characterized by a progressive increase in erosion of villi and elevated numbers of goblet cells, which could be related to the early expulsion of the parasite in a host of low compatibility. In contrast to rats, the number of goblet cell in E. caproni-infected hamsters was low, but increased numbers of neutrophils and mesenteric inflammatory cells were observed. This indicated that local inflammatory responses in hamsters were greater than in rats. An immunohistochemical study using polyclonal IgG anti-E. caproni excretory-secretory antigens demonstrated a greater level of passage of E. caproni antigens through the intestinal mucosa in hamsters than in rats, probably in relation to the greater inflammatory response. Our results indicate the fact that early inflammatory responses could be important for the establishment of E. caproni chronic infections in highly compatible hosts.
在感染后15天和30天，比较了卡氏棘口吸虫（吸虫纲：棘口科）在高兼容性宿主（金黄仓鼠）和低兼容性宿主（大鼠）中引起的组织病理学变化。大鼠感染的特征是绒毛侵蚀逐渐增加，杯状细胞数量增多，这可能与寄生虫在低兼容性宿主中的早期排出有关。与大鼠不同，感染卡氏棘口吸虫的仓鼠杯状细胞数量较少，但观察到中性粒细胞和肠系膜炎症细胞数量增加。这表明仓鼠的局部炎症反应比大鼠更强烈。一项使用抗卡氏棘口吸虫排泄-分泌抗原的多克隆IgG进行的免疫组织化学研究表明，卡氏棘口吸虫抗原通过仓鼠肠黏膜的程度比大鼠更高，这可能与更强的炎症反应有关。我们的结果表明，早期炎症反应对于卡氏棘口吸虫在高兼容性宿主中建立慢性感染可能很重要。
