Division of Neurological Disorders and Mental Health, Department of Health Sciences, National Natural Science Foundation of China, Beijing, 100085, China.
Neurosci Bull. 2013 Feb;29(1):94-102. doi: 10.1007/s12264-012-1277-8. Epub 2012 Nov 3.
Spinal cord injury (SCI) can have a range of debilitating effects and permanently alter the capabilities and quality of life of survivors. The first specialized centers of care for SCI were established in 1944 and since then an increasing amount of research has been carried out in this area. Despite this, the present treatment and care levels for SCI are not comparable to those in other areas of medicine. In the clinic, the aim of SCI treatment is primarily to limit secondary damage by reducing compression in trauma spots and stabilizing the spinal column. Currently, no effective strategy for functional recovery is offered. In this review, we focus on research progress on the molecular mechanisms underlying SCI, and assess the treatment outcomes of SCI in animal models, i.e., neurotrophins and stem cells are discussed as pre-clinical therapies in animal models. We also assess the resources available and national research projects carried out on SCI in China in recent years, as well as making recommendations for the future allocation of funds in this area.
脊髓损伤 (SCI) 会产生一系列使人衰弱的影响，并永久改变幸存者的能力和生活质量。1944 年，第一个专门的 SCI 护理中心成立，此后，该领域的研究不断增加。尽管如此，目前 SCI 的治疗和护理水平仍无法与其他医学领域相媲美。在临床上，SCI 治疗的主要目标是通过减少创伤部位的压迫和稳定脊柱来限制继发性损伤。目前，还没有提供有效的功能恢复策略。在这篇综述中，我们重点关注 SCI 相关分子机制的研究进展，并评估动物模型中 SCI 的治疗结果，即讨论神经生长因子和干细胞作为动物模型中的临床前治疗方法。我们还评估了近年来中国在 SCI 方面的可用资源和国家研究项目，并就该领域未来的资金分配提出建议。
