Zilberman M V, Khoury P R, Kimball R T
Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Pediatr Cardiol. 2005 Jul-Aug;26(4):356-60. doi: 10.1007/s00246-004-0736-z.
The goal of this study was to create nomograms of echocardiographic two-dimensional valve dimensions based on a large group of children without heart disease. Children aged 0-18 years underwent standard echocardiographic evaluation. Referring diagnoses were chest pain, heart murmur, or syncope. Only patients with a structurally normal heart and normal systolic and diastolic function were included. All four valves were measured at their maximal dimensions. A total of 748 children (314 girls and 434 boys) met the inclusion criteria. Mean values and standard deviations were calculated, and z value nomograms based on body surface area were developed. Surprisingly, the boys had larger valve dimensions at all ages. These valve dimension differences were statistically significant for three of four valves even after adjustment for the differences in body sizes. The difference may be due to higher circulating blood volume in boys compared to that in girls. Because the differences are subtle, they reach statistical significance only when evaluated in a large group of subjects. Presented normal value data will be helpful in following cardiology patients and evaluating intervention strategy in patients with valve hypoplasia.
本研究的目的是基于一大群无心脏病的儿童创建超声心动图二维瓣膜尺寸的列线图。0至18岁的儿童接受了标准的超声心动图评估。相关诊断包括胸痛、心脏杂音或晕厥。仅纳入心脏结构正常且收缩和舒张功能正常的患者。测量了所有四个瓣膜的最大尺寸。共有748名儿童（314名女孩和434名男孩）符合纳入标准。计算了平均值和标准差，并绘制了基于体表面积的z值列线图。令人惊讶的是，男孩在所有年龄段的瓣膜尺寸都更大。即使在调整了体型差异之后，四个瓣膜中的三个瓣膜尺寸差异仍具有统计学意义。这种差异可能是由于男孩的循环血容量高于女孩。由于差异细微，只有在对一大群受试者进行评估时才具有统计学意义。所呈现的正常值数据将有助于跟踪心脏病患者并评估瓣膜发育不全患者的干预策略。
