Polich John, Corey-Bloom Jody
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Curr Alzheimer Res. 2005 Dec;2(5):515-25. doi: 10.2174/156720505774932214.
Early stage Alzheimer disease patients and matched elderly unaffected controls (n = 16/group) were evaluated with the P300 event-related brain potential (ERP). All subjects performed four oddball tasks that varied systematically in task difficulty and were each presented in the auditory and visual modalities. P300 amplitude was smaller and peak latency longer for the Alzheimer patients compared to elderly control subjects across tasks and modalities. P300 differences between Alzheimer patients and controls were largest for the relatively easy tasks, with little influence of stimulus modality observed. The results suggest that the P300 brain potential is sensitive to Alzheimer's disease processes during its early stages, and that easily performed stimulus discrimination tasks are the clinically most useful. Theoretical and practical implications are reviewed.
对早期阿尔茨海默病患者和匹配的未受影响的老年对照者（每组16人）进行了P300事件相关脑电位（ERP）评估。所有受试者都执行了四项难度系统变化的oddball任务，每项任务都以听觉和视觉形式呈现。与老年对照受试者相比，阿尔茨海默病患者在所有任务和形式中的P300波幅较小，峰值潜伏期较长。阿尔茨海默病患者与对照者之间的P300差异在相对简单的任务中最大，观察到刺激形式的影响很小。结果表明，P300脑电位在阿尔茨海默病早期阶段对其病程敏感，且易于执行的刺激辨别任务在临床上最有用。对理论和实际意义进行了综述。
