与年龄相关性黄斑变性相关的浆液性和玻璃膜疣样色素上皮脱离的眼底自发荧光成像
Fundus autofluorescence imaging in serous and drusenoid pigment epithelial detachments associated with age-related macular degeneration.
作者信息
Karadimas Panagiotis, Bouzas Evrydiki A
机构信息
Medical Retina Unit, 1st Department of Ophthalmology, Henry Dunant Hospital, 107 Mesogion Avenue, 11526 Athens, Greece.
出版信息
Am J Ophthalmol. 2005 Dec;140(6):1163-5. doi: 10.1016/j.ajo.2005.07.037.
PURPOSE
To investigate the fundus autofluorescence (FAF) imaging findings in patients with serous and drusenoid pigment epithelial detachment (PED) associated with age-related macular degeneration (AMD).
DESIGN
Observational case series.
METHODS
Fourteen eyes of 13 consecutive patients with serous (n = 10) and drusenoid (n = 4) PED were prospectively included.
RESULTS
In all cases of serous vascularized (n = 7) and avascular (n = 3) PED, the FAF signal was increased, corresponding to the area of detachment. In drusenoid PED, the FAF was either increased or decreased. The decreased signal was recorded in cases associated with pigmented clumping.
CONCLUSIONS
These findings are useful for a more detailed phenotyping of patients with PED associated with AMD. FAF may derive not only from lipofuscin, but also from other sources, such as sub-retinal pigment epithelium fluid.
目的
研究与年龄相关性黄斑变性（AMD）相关的浆液性和玻璃膜疣样色素上皮脱离（PED）患者的眼底自发荧光（FAF）成像表现。
设计
观察性病例系列。
方法
前瞻性纳入13例连续患者的14只眼，其中浆液性PED患者10例，玻璃膜疣样PED患者4例。
结果
在所有浆液性血管化（n = 7）和无血管（n = 3）PED病例中，FAF信号增强，与脱离区域相对应。在玻璃膜疣样PED中，FAF信号可增强或减弱。信号减弱见于伴有色素聚集的病例。
结论
这些发现有助于对与AMD相关的PED患者进行更详细的表型分析。FAF可能不仅来源于脂褐素，还可能来源于其他来源，如视网膜色素上皮下液。
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