莫西沙星对从人类腹腔内感染分离出的923株厌氧菌的体外活性。
In vitro activity of moxifloxacin against 923 anaerobes isolated from human intra-abdominal infections.
作者信息
Goldstein Ellie J C, Citron Diane M, Warren Yumi A, Tyrrell Kerin L, Merriam C Vreni, Fernandez Helen
机构信息
R. M. Alden Research Laboratory, 2021 Santa Monica Blvd., Suite #740 East, Santa Monica, California 90404, USA.
出版信息
Antimicrob Agents Chemother. 2006 Jan;50(1):148-55. doi: 10.1128/AAC.50.1.148-155.2006.
The in vitro activity of moxifloxacin against 923 recent anaerobic isolates obtained from pretreatment cultures in patients with complicated intra-abdominal infections was studied using the CLSI M11-A-6 agar dilution method. Moxifloxacin was active against 87% (96 of 110) Bacteroides fragilis strains at < or = 1 microg/ml and 87% (79 of 90) B. thetaiotaomicron strains at < or = 2 microg/ml. Species variation was seen, with B. uniformis, B. vulgatus, Clostridium clostridioforme, and C. symbiosum being least susceptible and accounting for most of the resistant isolates; excluding the aforementioned four resistant species, 86% (303 of 363) of Bacteroides species isolates and 94% (417 of 450) of all other genera and species were susceptible to < or = 2 microg/ml of moxifloxacin. Overall, moxifloxacin was active against 763 of 923 (83%) of strains at < or = 2 microg/ml, supporting its use as a monotherapy for some community-acquired intra-abdominal infections.
采用CLSI M11-A-6琼脂稀释法，研究了莫西沙星对923株近期从复杂性腹腔内感染患者预处理培养物中分离出的厌氧菌的体外活性。莫西沙星对87%（110株中的96株）的脆弱拟杆菌菌株在浓度≤1微克/毫升时具有活性，对87%（90株中的79株）的多形拟杆菌菌株在浓度≤2微克/毫升时具有活性。观察到种间差异，其中解脲拟杆菌、普通拟杆菌、梭状芽孢梭菌和共生梭菌最不敏感，且大多数耐药菌株均为此类；排除上述四种耐药菌，86%（363株拟杆菌属菌株中的303株）和94%（450株其他属和种中的417株）对浓度≤2微克/毫升的莫西沙星敏感。总体而言，莫西沙星对923株中的763株（83%）菌株在浓度≤2微克/毫升时具有活性，这支持了其作为某些社区获得性腹腔内感染单一疗法的应用。
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