Hammar N, Ahlbom A, Theorell T
Department of Epidemiology, Karolinska Institutet, Stockholm, Sweden.
Epidemiology. 1992 Jul;3(4):348-55. doi: 10.1097/00001648-199207000-00010.
Considerable regional variation in coronary heart disease mortality has been observed in Sweden. This variation is of public health concern and is also a point of departure for etiologic studies. The central aim of the present study was to investigate whether there are also regional differences in myocardial infarction incidence and to evaluate whether these are likely to be explained by regional differences in smoking, blood pressure, and serum cholesterol. The study base consisted of subjects age 30-64 living in eight Swedish counties during 1976-1981. Cases of myocardial infarction were identified using both hospital discharge and death records. A 30-40% increased incidence of myocardial infarction was found in the two northernmost counties compared with Stockholm county. The regional differences in myocardial infarction incidence were not related to differences in smoking but might be due in part to differences in serum cholesterol and blood pressure, and to socioeconomic factors as well.
在瑞典，已观察到冠心病死亡率存在显著的地区差异。这种差异引起了公共卫生方面的关注，也是病因学研究的出发点。本研究的核心目的是调查心肌梗死发病率是否也存在地区差异，并评估这些差异是否可能由吸烟、血压和血清胆固醇的地区差异所解释。研究对象为1976年至1981年期间居住在瑞典八个县的30至64岁人群。通过医院出院记录和死亡记录来确定心肌梗死病例。与斯德哥尔摩县相比，最北部的两个县心肌梗死发病率增加了30%至40%。心肌梗死发病率的地区差异与吸烟差异无关，但可能部分归因于血清胆固醇和血压的差异，以及社会经济因素。
