Sharifian Akbar, Farahani Saeed, Pasalar Parvin, Gharavi Marjan, Aminian Omid
Department of Occupational Medicine, Tehran University of Medical Sciences, Tehran, Iran.
J Circadian Rhythms. 2005 Dec 28;3:15. doi: 10.1186/1740-3391-3-15.
Some medical disorders have higher prevalence in shift workers than others. This study was designed to evaluate the effect of night-shift-working on total plasma antioxidant capacity, with respect to the causative role of oxidative stress in induction of some of these disorders.
Two blood samples were taken from 44 workers with a rotational shift schedule, one after their day shift and one after their night shift. The total plasma antioxidant capacity of each worker was measured through the FRAP method. The impacts of age and weight were also assessed.
The total plasma antioxidant capacity was measured in 44 shift-workers with a mean age of 36.57 years (SD: 10.18) and mean BMI of 26.06 (SD: 4.37) after their day and night shifts. The mean reduction of total plasma antioxidant capacity after the night shift was 105.8 micromol/L (SD: 146.39). Also, a significant correlation was shown between age and weight and total plasma antioxidant capacity. Age and weight were found to be inversely related to total plasma antioxidant capacity; as age and weight increased, the total plasma antioxidant capacity decreased.
Shift work can act as an oxidative stressor and may induce many medical disorders. Aging and obesity in shift workers makes them more sensitive to this hazardous effect.
某些医学病症在轮班工作者中的患病率高于其他人。本研究旨在评估夜班工作对血浆总抗氧化能力的影响，探讨氧化应激在引发其中一些病症中的作用。
对44名实行轮班制的工作者采集两份血样，一份在白班后采集，一份在夜班后采集。通过FRAP法测量每名工作者的血浆总抗氧化能力。同时评估年龄和体重的影响。
对44名轮班工作者进行了血浆总抗氧化能力测量，这些工作者平均年龄为36.57岁（标准差：10.18），平均体重指数为26.06（标准差：4.37），分别在白班和夜班后进行测量。夜班后血浆总抗氧化能力平均降低105.8微摩尔/升（标准差：146.39）。此外，年龄、体重与血浆总抗氧化能力之间存在显著相关性。年龄和体重与血浆总抗氧化能力呈负相关；随着年龄和体重增加，血浆总抗氧化能力下降。
轮班工作可作为一种氧化应激源，可能引发多种医学病症。轮班工作者的衰老和肥胖使他们对这种有害影响更为敏感。
