Mount D W, Walker A C, Kosel C
J Bacteriol. 1975 Mar;121(3):1203-7. doi: 10.1128/jb.121.3.1203-1207.1975.
It has been shown previously that the radiation sensitivity of lexA- strains of Escherichia coli K-12 can be suppressed by thermosensitive mutations (designated tsl) that are closely linked to the lexA locus and are thought to be intragenic suppressors of lexA mutations (Mount et al., 1973). When a recA mutation is crossed into a suppressed tsl- strain, the extreme radiation sensitivity usually conferred by a recA mutation is decreased, but there is no detectable change in genetic recombination deficiency. Increased resistance to UV in the tsl-reA-strains depends upon ability to synthesize active uvrA+ product.
先前已经表明,大肠杆菌K-12的lexA-菌株的辐射敏感性可被与lexA基因座紧密连锁的热敏突变(称为tsl)所抑制,这些突变被认为是lexA突变的基因内抑制子(Mount等人,1973年)。当将recA突变引入受抑制的tsl-菌株时,recA突变通常赋予的极端辐射敏感性会降低,但遗传重组缺陷没有可检测到的变化。tsl-recA-菌株对紫外线的抗性增加取决于合成活性uvrA+产物的能力。