Sasaki Ken, Watanabe Masanori, Suda Yoshito, Ishizuka Akihiro, Noparatnaraporn Napavarn
Materials Science and Engineering, Graduate School of Engineering, Hiroshima Kokusai Gakuin University, 6-20-1 Nakano, Akiku, Hiroshima 739-0321, Japan.
J Biosci Bioeng. 2005 Nov;100(5):481-8. doi: 10.1263/jbb.100.481.
The medical applications of photosynthetic bacteria are summarized. Photosynthetic bacteria can produce various types of physiological active substance such as vitamin B(12), ubiquinone (coenzyme Q10), 5-aminolevulinic acid (ALA), porphyrins and RNA. In particular, photosynthetic bacterial ALA was commercially applied to cancer diagnosis and treatment. Recently, ALA has been applied to the treatment of acne vulgaris and the suppression of the inflammatory response to coronary and iliac injuries. In addition, the recent applications of RNA from a marine photosynthetic bacterium as a medical supplement for immune improvement and suppression of infection are described. Furthermore, the feasible application of a biopolymer consisting of RNA from a photosynthetic bacterium as a drug delivery system (DDS) to cancer treatment is described.
总结了光合细菌的医学应用。光合细菌能产生多种生理活性物质,如维生素B12、泛醌(辅酶Q10)、5-氨基乙酰丙酸(ALA)、卟啉和RNA。特别是,光合细菌ALA已商业化应用于癌症诊断和治疗。最近,ALA已应用于寻常痤疮的治疗以及对冠状动脉和髂动脉损伤炎症反应的抑制。此外,还描述了一种海洋光合细菌的RNA作为改善免疫和抑制感染的医学补充剂的最新应用。此外,还描述了一种由光合细菌的RNA组成的生物聚合物作为药物递送系统(DDS)在癌症治疗中的可行应用。