Hatin I, Trape J F, Legros F, Bauchet J, Le Bras J
Centre National de Référence de la Chimiosensibilité du Paludisme, Paris, France.
Bull World Health Organ. 1992;70(3):363-7.
A total of 47 nonimmune febrile patients from Pikine, Senegal, with greater than 1,000 Plasmodium falciparum asexual forms per microliter whole blood were given 12.5 mg per kg body weight of mefloquine in a single oral dose and were followed up daily until day 7 and also on day 14 of the study. Seven of the patients who vomited, four who had 4-aminoquinolines in their blood, and five dropouts were excluded. Fever and parasitaemia were suppressed within four days until day fourteen in 29 of the 31 remaining patients, including 10 with P. falciparum strains that had a low sensitivity to mefloquine. Two failures were due to poor absorption of mefloquine. The presence of P. falciparum strains with low in vitro susceptibility to mefloquine did not affect, within 14 days, the clinical and parasitological efficacy of a single oral dose mefloquine regimen in patients who had received no previous antimalarial treatment and who did not have partial immune protection.
来自塞内加尔皮金的47名非免疫性发热患者，每微升全血中恶性疟原虫无性体超过1000个，给予单剂量口服12.5毫克/千克体重的甲氟喹，并在研究的第7天前每日随访，在第14天也进行随访。7名呕吐患者、4名血液中有4-氨基喹啉的患者和5名退出者被排除。在剩下的31名患者中，有29名患者在第4天至第14天期间发热和寄生虫血症得到抑制，其中包括10名对甲氟喹敏感性较低的恶性疟原虫菌株患者。2例治疗失败是由于甲氟喹吸收不良。在体外对甲氟喹敏感性较低的恶性疟原虫菌株的存在，在14天内并未影响未接受过抗疟治疗且没有部分免疫保护的患者单剂量口服甲氟喹方案的临床和寄生虫学疗效。
