Seppänen Allan, Autio-Harmainen Helena, Alafuzoff Irina, Särkioja Terttu, Veijola Johanna, Hurskainen Tiina, Bruckner-Tuderman Leena, Tasanen Kaisa, Majamaa Kari
Department of Neurology, University of Oulu and Clinical Research Center, Oulu University Hospital, FIN-90014 Oulu, Finland.
Matrix Biol. 2006 Apr;25(3):185-8. doi: 10.1016/j.matbio.2005.11.004. Epub 2006 Jan 4.
Type XVII collagen (collagen XVII) is a component of hemidesmosomes, which connect epithelial cells to the underlying basement membrane. Previously, an association has been suggested between neurological disorders and the skin disease bullous pemphigoid, where autoimmunity is directed against collagen XVII. Furthermore, the lack of alpha6 integrin, a ligand of collagen XVII, has been implicated in defects of cortical organization in the mouse brain. In this study, we demonstrate for the first time the presence of collagen XVII in neurons of the human brain by in situ hybridisation, immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR). We propose that collagen XVII may be involved in the pathogenesis of various disorders affecting neuronal migration or synaptic plasticity.
ⅩⅦ型胶原蛋白（胶原蛋白ⅩⅦ）是半桥粒的一个组成部分，半桥粒将上皮细胞与下方的基底膜相连。此前，有人提出神经疾病与自身免疫针对胶原蛋白ⅩⅦ的皮肤病大疱性类天疱疮之间存在关联。此外，胶原蛋白ⅩⅦ的配体α6整合素的缺失与小鼠大脑皮质组织缺陷有关。在本研究中，我们首次通过原位杂交、免疫组织化学和逆转录聚合酶链反应（RT-PCR）证明了人脑中神经元存在胶原蛋白ⅩⅦ。我们提出，胶原蛋白ⅩⅦ可能参与影响神经元迁移或突触可塑性的各种疾病的发病机制。
