Suppr超能文献

吸入性糖皮质激素:对支气管哮喘气道血管系统的影响

Inhaled corticosteroids: effects on the airway vasculature in bronchial asthma.

作者信息

Horvath G, Wanner A

机构信息

Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine, Miami, FL 33101, USA.

出版信息

Eur Respir J. 2006 Jan;27(1):172-87. doi: 10.1183/09031936.06.00048605.

Abstract

Inhaled corticosteroids suppress airway inflammation and components of airway remodelling in bronchial asthma. In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). Corticosteroids are now known to exert their effects on the airway vasculature through genomic and nongenomic mechanisms. Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. In contrast, nongenomic actions are mediated by rapid cellular mechanisms, and induce transient vasoconstriction in the airway, thereby reversing inflammatory hyperperfusion. The vascular actions of corticosteroids contribute to controlling clinical symptoms of asthma primarily by influencing airway calibre in the lung periphery and airway hyperreactivity. In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed.

摘要

吸入性糖皮质激素可抑制支气管哮喘中的气道炎症和气道重塑成分。在气管支气管(气道)脉管系统中,这些作用包括抑制炎症性充血、微血管通透性增加、黏膜水肿形成以及新血管形成(血管生成)。现在已知糖皮质激素通过基因组和非基因组机制对气道脉管系统发挥作用。基因组作用涉及靶基因的调控,并抑制气道炎症和血管生成的大多数血管相关成分。相比之下,非基因组作用由快速细胞机制介导,并诱导气道短暂血管收缩,从而逆转炎症性充血。糖皮质激素的血管作用主要通过影响肺外周气道口径和气道高反应性来控制哮喘的临床症状。在这篇综述文章中,我们综述了对吸入性糖皮质激素与哮喘气道脉管系统相互作用的细胞机制及临床意义的最新认识进展。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验