Department of Physiotherapy and Rehabilitation, Health Science Faculty, Ege University, İzmir, Turkey.
Department of Physiotherapy and Rehabilitation, Health Science Faculty, Medipol University, Istanbul, Turkey.
Eur J Pediatr. 2023 Aug;182(8):3713-3722. doi: 10.1007/s00431-023-05047-4. Epub 2023 Jun 7.
Airway inflammation characterized as asthma is one of the most common chronic diseases in the world. The aim of this study was to evaluate the possible effect of inspiratory muscle training on inflammation markers and oxidative stress levels in childhood asthma. A total of 105 children (age range 8-17 years), including 70 asthmatics and 35 healthy children, participated in the study. The 70 asthma patients were randomly assigned to the inspiratory muscle training (IMT) group (n = 35) and control group (n = 35), and healthy children were assigned to the healthy group (n = 35). The IMT group was treated with the threshold IMT device for 7 days/6 weeks at 30% of maximum inspiratory pressure. Respiratory muscle strength was evaluated with a mouth pressure measuring device, and respiratory function was evaluated with a spirometer. In addition, CRP, periostin, TGF-β, and oxidative stress levels were analyzed. The evaluation was performed only once in the healthy group and twice (at the beginning and end of 6 weeks) in asthma patients. In the study, there were significant differences between asthma patients and the healthy group in terms of MIP and MEP values, respiratory function, oxidative stress level, periostin, and TGF-β. Post-treatment, differences were observed in the oxidative stress level, periostin, and TGF-β of the IMT group (p < .05).
After 6 weeks of training, IMT positively contributed to reducing the inflammation level and oxidative stress. This suggests that IMT should be used as an alternative therapy to reduce inflammation and oxidative stress. (Trial Registration: The clinical trial protocol number is NCT05296707).
• It is known that adjunctive therapies given in addition to pharmacological treatment contribute to improving symptom control and quality of life in individuals with asthma.
• There are no studies about the effect of respiratory physiotherapy on biomarkers in asthmatic children. The sub-mechanism of improvement in individuals has not been elucidated. • In this context, inspiratory muscle training has a positive effect on inflammation and oxidative stress levels in children with asthma and IMT should be used as an alternative treatment for childhood asthma.
气道炎症表现为哮喘，是世界上最常见的慢性疾病之一。本研究旨在评估吸气肌训练对儿童哮喘炎症标志物和氧化应激水平的可能影响。共有 105 名儿童（年龄 8-17 岁），包括 70 名哮喘患儿和 35 名健康儿童，参与了本研究。70 名哮喘患儿被随机分为吸气肌训练（IMT）组（n=35）和对照组（n=35），健康儿童分为健康组（n=35）。IMT 组使用阈吸气压训练仪，在最大吸气压力的 30%下进行 7 天/6 周的治疗。通过口腔压力测量仪评估呼吸肌力量，通过肺活量计评估呼吸功能。此外，还分析了 CRP、骨膜蛋白、TGF-β和氧化应激水平。健康组仅进行一次评估，哮喘患者进行两次评估（治疗前和 6 周结束时）。研究中，哮喘患儿与健康组在 MIP 和 MEP 值、呼吸功能、氧化应激水平、骨膜蛋白和 TGF-β方面存在显著差异。治疗后，IMT 组的氧化应激水平、骨膜蛋白和 TGF-β 有差异（p<.05）。
经过 6 周的训练，IMT 有助于降低炎症水平和氧化应激。这表明 IMT 应该作为一种替代疗法，用于减轻炎症和氧化应激。（试验注册号：NCT05296707）。
• 已知除药物治疗外，辅助治疗有助于改善哮喘患者的症状控制和生活质量。
• 尚无关于呼吸物理治疗对哮喘儿童生物标志物影响的研究。个体改善的亚机制尚未阐明。• 在这种情况下，吸气肌训练对哮喘儿童的炎症和氧化应激水平有积极影响，IMT 应作为儿童哮喘的替代治疗方法。
