Green Elaine K, Raybould Rachel, Macgregor Stuart, Hyde Sally, Young Allan H, O'Donovan Michael C, Owen Michael J, Kirov George, Jones Lisa, Jones Ian, Craddock Nick
Department of Psychological Medicine, Henry Wellcome Building, Wales College of Medicine, Cardiff University, Heath Park, Cardiff CF4 4XN, Wales, UK.
Br J Psychiatry. 2006 Jan;188:21-5. doi: 10.1192/bjp.bp.105.009969.
Brain-derived neurotrophic factor (BDNF) influences neuronal survival, proliferation and plasticity. Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder.
To replicate this finding.
We genotyped the Val66Met polymorphism in our UK White bipolar case-control sample (n=3062).
We found no overall evidence of allele or genotype association. However, we found association with disease status in the subset of 131 individuals that had experienced rapid cycling at some time (P=0.004). We found a similar association on re-analysis of our previously reported family-based association sample (P < 0.03, one-tailed test).
Variation at the Val66Met polymorphism of BDNF does not play a major role in influencing susceptibility to bipolar disorder as a whole, but is associated with susceptibility to the rapid-cycling subset of the disorder.
脑源性神经营养因子（BDNF）影响神经元的存活、增殖和可塑性。三项基于家族的研究表明，BDNF基因Val66Met多态性的常见缬氨酸（Val）等位基因与双相情感障碍易感性相关。
重复这一发现。
我们对英国白人双相情感障碍病例对照样本（n = 3062）中的Val66Met多态性进行了基因分型。
我们未发现等位基因或基因型关联的总体证据。然而，我们在131名曾在某些时候经历过快速循环发作的个体亚组中发现了与疾病状态的关联（P = 0.004）。在对我们之前报道的基于家族的关联样本进行重新分析时，我们发现了类似的关联（P < 0.03，单尾检验）。
BDNF基因Val66Met多态性的变异在整体上对双相情感障碍易感性的影响并不起主要作用，但与该疾病快速循环发作亚组的易感性相关。
