Rogers T J, DeHaven J I, Donnelly R P, Lamb B
Cell Immunol. 1984 Sep;87(2):703-7. doi: 10.1016/0008-8749(84)90039-x.
It has been shown that T cells cultured with prostaglandin E2 are induced to release at least two peptide-containing lymphokines (PITS). Both the high-molecular-weight (35,000; PITS alpha) and the low-molecular-weight (2000 to 5000; PITS beta) factors were shown to be potent inhibitors of both T-cell- and B-cell-dependent mitogen responses. Data are reported here which show that the PITS beta factor may be reproducibly resolved into seven components by high-pressure liquid chromatography. Although each of these components is capable of suppressing the phytohemagglutinin-induced blastogenic response, not all of these factors will suppress the in vitro antibody response to sheep erythrocytes, or a mixed lymphocyte reaction. Nevertheless, the broad-range suppressive effects previously reported for PITS beta now seem to be mediated by multiple low-molecular-weight PITS factors.
已经表明，与前列腺素E2一起培养的T细胞被诱导释放至少两种含肽的淋巴因子（PITS）。高分子量（35,000；PITSα）和低分子量（2000至5000；PITSβ）因子均显示为T细胞和B细胞依赖性有丝分裂原反应的有效抑制剂。本文报道的数据表明，PITSβ因子可通过高压液相色谱法可重复地解析为七个组分。尽管这些组分中的每一个都能够抑制植物血凝素诱导的增殖反应，但并非所有这些因子都会抑制对绵羊红细胞的体外抗体反应或混合淋巴细胞反应。然而，先前报道的PITSβ的广泛抑制作用现在似乎是由多种低分子量PITS因子介导的。
