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从日本太平洋沿岸分离出的假交替单胞菌属1020R中的细胞毒性灵菌红素家族色素。

Cytotoxic prodigiosin family pigments from Pseudoalteromonas sp. 1020R isolated from the Pacific coast of Japan.

作者信息

Wang Yi, Nakajima Aya, Hosokawa Kakushi, Soliev Azamjon B, Osaka Issey, Arakawa Ryuichi, Enomoto Keiichi

机构信息

Department of Environmental Systems Engineering, Kochi University of Technology, Kochi, Japan.

出版信息

Biosci Biotechnol Biochem. 2012;76(6):1229-32. doi: 10.1271/bbb.110984. Epub 2012 Jun 7.

DOI:10.1271/bbb.110984
PMID:22790952
Abstract

Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.

摘要

从日本太平洋沿岸分离出的假交替单胞菌1020R可产生灵菌红素家族色素。结构分析表明，这些色素为灵菌红素（2-甲基-3-戊基-灵菌红素）以及其他三种仅在烷基侧链长度上有所不同的灵菌红素同系物。这些化合物对U937白血病细胞表现出不同程度的细胞毒性，且细胞死亡伴有典型的凋亡特征。

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