Galper Daniel I, Trivedi Madhukar H, Barlow Carolyn E, Dunn Andrea L, Kampert James B
Mood Disorders Research Program and Clinic, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA.
Med Sci Sports Exerc. 2006 Jan;38(1):173-8. doi: 10.1249/01.mss.0000180883.32116.28.
The Aerobics Center Longitudinal Study (ACLS) provides the opportunity to evaluate associations between measures of physical activity and mental health in a large and well-characterized population of men and women.
Participants were 5451 men and 1277 women (20-88 yr) who completed a maximal fitness treadmill test and self-report measures of habitual physical activity, depressive symptoms (Center for Epidemiological Studies Scale for Depression; CES-D) and emotional well-being (General Well-Being Schedule; GWB). To evaluate the dose-response gradient of the association, we classified the sample, separately for men and women, into three levels of relative cardiorespiratory (CR) fitness (low, moderate, high) on the maximal treadmill test, and four levels on a physical activity index of weekly walking, jogging, and running.
In both men and women, there was a significant inverse graded dose-response relationship between maximal CR fitness and the CES-D score (P < 0.0001), and a significant positive graded dose-response relationship between CR fitness and the GWB score (P < 0.0001). We also observed dose-response associations between the level of physical activity and both CES-D and GWB scores (P < 0.0001) that peaked at 11-19 miles per week.
Among men and women in the ACLS, relative increases in maximal CR fitness and habitual physical activity are cross-sectionally associated with lower depressive symptomatology and greater emotional well-being. Prospective epidemiological studies and controlled clinical trials are needed to identify the minimal and optimal levels of physical activity and CR fitness associated with various mental health benefits in different segments of the general population.
有氧运动中心纵向研究（ACLS）提供了一个机会，可在一个大规模且特征明确的男性和女性人群中评估身体活动指标与心理健康之间的关联。
参与者为5451名男性和1277名女性（年龄在20 - 88岁之间），他们完成了最大运动能力跑步机测试以及习惯性身体活动、抑郁症状（流行病学研究中心抑郁量表；CES - D）和情绪幸福感（总体幸福感量表；GWB）的自我报告测量。为了评估这种关联的剂量反应梯度，我们根据最大跑步机测试，将样本按男性和女性分别分为相对心肺（CR）适能的三个水平（低、中、高），并根据每周步行、慢跑和跑步的身体活动指数分为四个水平。
在男性和女性中，最大CR适能与CES - D得分之间均存在显著的反向分级剂量反应关系（P < 0.0001），CR适能与GWB得分之间存在显著的正向分级剂量反应关系（P < 0.0001）。我们还观察到身体活动水平与CES - D和GWB得分之间的剂量反应关联（P < 0.0001），在每周11 - 19英里时达到峰值。
在ACLS的男性和女性中，最大CR适能和习惯性身体活动的相对增加与较低的抑郁症状和更高的情绪幸福感呈横断面关联。需要进行前瞻性流行病学研究和对照临床试验，以确定在一般人群的不同亚组中，与各种心理健康益处相关的身体活动和CR适能的最低和最佳水平。
