Volanen Iina, Järvisalo Mikko J, Vainionpää Raija, Arffman Martti, Kallio Katariina, Anglé Susanna, Rönnemaa Tapani, Viikari Jorma, Marniemi Jukka, Raitakari Olli T, Simell Olli
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):649-55. doi: 10.1161/01.ATV.0000202664.76816.bb. Epub 2006 Jan 5.
The relationship between Chlamydia pneumoniae (Cpn) infection and arterial measures of preclinical atherosclerosis has remained controversial. Because atherogenesis begins in early life, we examined whether carotid and aortic intima-media thickness (IMT) and brachial artery endothelial function are associated with Cpn seropositivity in children.
Cpn-specific IgG and IgA antibodies were assessed by enzyme immunoassay in 199 healthy children followed-up annually from 7 to 11 years of age. Carotid (cIMT) and aortic IMT (aIMT), and brachial artery flow-mediated dilatation (FMD) were measured in 137 of the 199 children at the age of 11 years using high-resolution ultrasound. Children with persistent IgG and/or IgA seropositivity to Cpn had significantly increased aIMT compared with seronegative children (IgG< or =45 and IgA< or =12 enzyme immunounits) or children with transient Cpn seropositivity (seronegative, 0.496 [0.054]; transient, 0.494 [0.061]; and persistent, 0.532 [0.086] mm; P<0.05 for trend). This trend was not explained by traditional atherosclerotic risk factors or pubertal stage. cIMT and FMD were not associated with Cpn seropositivity.
Eleven-year-old children with persistent Cpn seropositivity show increased aIMT but not cIMT, suggesting that Cpn may affect the aortic wall, the site where the earliest atherosclerotic lesions are known to occur, in otherwise healthy children.
肺炎衣原体（Cpn）感染与临床前期动脉粥样硬化的动脉指标之间的关系一直存在争议。由于动脉粥样硬化始于生命早期，我们研究了儿童的颈动脉和主动脉内膜中层厚度（IMT）以及肱动脉内皮功能是否与Cpn血清阳性有关。
采用酶免疫测定法对199名7至11岁每年接受随访的健康儿童检测Cpn特异性IgG和IgA抗体。在199名儿童中的137名11岁儿童中，使用高分辨率超声测量颈动脉（cIMT）和主动脉IMT（aIMT）以及肱动脉血流介导的舒张功能（FMD）。与血清阴性儿童（IgG≤45且IgA≤12酶免疫单位）或Cpn血清阳性短暂的儿童相比，Cpn持续IgG和/或IgA血清阳性的儿童aIMT显著增加（血清阴性，0.496 [0.054]；短暂阳性，0.494 [0.061]；持续阳性，0.532 [0.086] mm；趋势P<0.05）。这一趋势无法用传统动脉粥样硬化危险因素或青春期阶段来解释。cIMT和FMD与Cpn血清阳性无关。
Cpn血清持续阳性的11岁儿童显示aIMT增加，但cIMT未增加，这表明在其他方面健康的儿童中，Cpn可能会影响主动脉壁，即已知最早发生动脉粥样硬化病变的部位。
