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肺炎衣原体感染作为冠心病病因:该假说仍未得到验证。

Infection with Chlamydia pneumoniae as a cause of coronary heart disease: the hypothesis is still untested.

作者信息

Grayston J Thomas, Belland Robert J, Byrne Gerald I, Kuo Cho Chou, Schachter Julius, Stamm Walter E, Zhong Guangming

机构信息

Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195-7326, USA

Department of Microbiology, Immunology and Biochemistry, University of Tennessee, Health Science Center, Memphis, TN 38163, USA.

出版信息

Pathog Dis. 2015 Feb;73(1):1-9. doi: 10.1093/femspd/ftu015. Epub 2014 Dec 4.

DOI:10.1093/femspd/ftu015
PMID:25854002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4492408/
Abstract

Review of the possible role of infection in the pathogenesis of heart disease.

摘要

感染在心脏病发病机制中可能作用的综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6839/4492408/51375ed32547/ftu015fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6839/4492408/51375ed32547/ftu015fig1g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6839/4492408/51375ed32547/ftu015fig1g.jpg

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Ten years of next-generation sequencing technology.十年的下一代测序技术。
Trends Genet. 2014 Sep;30(9):418-26. doi: 10.1016/j.tig.2014.07.001. Epub 2014 Aug 6.
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Conducting a microbiome study.进行微生物组研究。
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Chlamydia pneumoniae negatively regulates ABCA1 expression via TLR2-Nuclear factor-kappa B and miR-33 pathways in THP-1 macrophage-derived foam cells.肺炎衣原体通过TLR2-核因子-κB和miR-33途径对THP-1巨噬细胞源性泡沫细胞中ABCA1的表达起负调控作用。
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Assaying Persistence in Monocyte-Derived Macrophages Identifies Dibenzocyclooctadiene Lignans as Phenotypic Switchers.检测单核细胞来源的巨噬细胞中的持久性可鉴定二苯并环辛二烯木脂素类作为表型转换剂。
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Clinical study of chlamydia pneumoniae infection in patients with coronary heart disease.冠心病患者肺炎衣原体感染的临床研究。
BMC Cardiovasc Disord. 2019 May 14;19(1):110. doi: 10.1186/s12872-019-1099-y.
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A retrospective seroepidemiologic survey of Chlamydia pneumoniae infection in patients in Beijing between 2008 and 2017.2008 年至 2017 年期间北京地区人群肺炎衣原体感染的血清流行病学调查回顾性研究。
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Tumor necrosis factor receptor superfamily members 1a and 1b contribute to exacerbation of atherosclerosis by Chlamydia pneumoniae in mice.肿瘤坏死因子受体超家族成员 1a 和 1b 通过肺炎衣原体促进小鼠动脉粥样硬化的恶化。
Microbes Infect. 2019 Mar;21(2):104-108. doi: 10.1016/j.micinf.2018.09.003. Epub 2018 Oct 4.
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Intranasal immunization with recombinant chlamydial protease-like activity factor attenuates atherosclerotic pathology following Chlamydia pneumoniae infection in mice.鼻腔内接种重组衣原体蛋白酶样活性因子可减轻小鼠感染肺炎衣原体后的动脉粥样硬化病理。
Immunol Cell Biol. 2019 Jan;97(1):85-91. doi: 10.1111/imcb.12192. Epub 2018 Aug 23.
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Biophysical and Biochemical Outcomes of Chlamydia pneumoniae Infection Promotes Pro-atherogenic Matrix Microenvironment.肺炎衣原体感染的生物物理和生化结果促进动脉粥样硬化前基质微环境。
Front Microbiol. 2016 Aug 17;7:1287. doi: 10.3389/fmicb.2016.01287. eCollection 2016.
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Immunopathogenesis of Chlamydial Infections.衣原体感染的免疫发病机制。
Curr Top Microbiol Immunol. 2018;412:183-215. doi: 10.1007/82_2016_18.
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Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences.基于 16S rRNA 标记基因序列对微生物群落进行功能预测分析。
Nat Biotechnol. 2013 Sep;31(9):814-21. doi: 10.1038/nbt.2676. Epub 2013 Aug 25.
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6
ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in Chlamydia pneumoniae infection.ABC 盒式转运蛋白 1(ABCA1)在肺炎衣原体感染中的上皮细胞中的表达。
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Detection of Mycoplasma pneumoniae and Chlamydophila pneumoniae directly from respiratory clinical specimens using a rapid real-time polymerase chain reaction assay.采用快速实时聚合酶链反应检测呼吸道临床标本中的肺炎支原体和肺炎衣原体。
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