Künig G, Kaldune A, Stief V, Jäger M, Hell D, Endrass J, Schreiter Gasser U
Gerontopsychiatrisches Zentrum Hegibach, Psychiatrische Universitätsklinik Zürich, Bülach.
Nervenarzt. 2007 Mar;78(3):314, 316-21. doi: 10.1007/s00115-005-2032-4.
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) is an established screening instrument for the diagnosis of Alzheimer's disease. The Nurses Observation Scale for Geriatric Patients (NOSGER), actually developed for rating the frequency of behavioral disturbances, appears suitable for dementia screening as well.
In this retrospective study we analyze the neuropsychological data of 400 consecutive patients at our hospital with several psychiatric diagnoses and cognitive deficits. By means of logistic calculation in single and multivariable models, the predictive value of CERAD and NOSGER for dementia diagnosis was studied.
All CERAD subtests were significant single predictors for dementia. The multivariable model with the highest prediction for probability of dementia diagnosis contained the subtests Verbal Fluency Test, Word List Recall, Constructional Practice Recall, and the Mini-Mental State Examination. However, NOSGER could not differentiate between demented and nondemented patients.
In our gerontopsychiatric population, CERAD separates demented patients from nondemented ones with high predictive potency. The NOSGER does not reveal any predictive value for the diagnosis of dementia.
阿尔茨海默病注册协会（CERAD）是一种已确立的用于诊断阿尔茨海默病的筛查工具。老年患者护士观察量表（NOSGER）实际上是为评估行为障碍的频率而开发的，似乎也适用于痴呆筛查。
在这项回顾性研究中，我们分析了我院400例连续患有多种精神疾病诊断和认知缺陷患者的神经心理学数据。通过单变量和多变量模型中的逻辑计算，研究了CERAD和NOSGER对痴呆诊断的预测价值。
所有CERAD子测试都是痴呆的显著单预测因子。对痴呆诊断概率预测最高的多变量模型包含言语流畅性测试、单词列表回忆、结构实践回忆和简易精神状态检查等子测试。然而，NOSGER无法区分痴呆患者和非痴呆患者。
在我们的老年精神病患者群体中，CERAD能以较高的预测效力将痴呆患者与非痴呆患者区分开来。NOSGER对痴呆诊断没有显示出任何预测价值。
