Mogilner Alex, Wollman Roy, Civelekoglu-Scholey Gul, Scholey Jonathan
Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, CA 95616, USA.
Trends Cell Biol. 2006 Feb;16(2):88-96. doi: 10.1016/j.tcb.2005.12.007. Epub 2006 Jan 10.
The mitotic spindle is a fascinating protein machine that uses bipolar arrays of dynamic microtubules and many mitotic motors to coordinate the accurate segregation of sister chromatids. Here we discuss recent mathematical models and computer simulations that, in concert with experimental studies, help explain the molecular mechanisms by which the spindle machinery performs its crucial functions. We review current models of spindle assembly, positioning, maintenance and elongation; of chromosome capture and congression; and of the spindle assembly checkpoint. We discuss some limitations of the application of modeling to other aspects of mitosis and the feasibility of building more comprehensive system-level models.
有丝分裂纺锤体是一种迷人的蛋白质机器，它利用动态微管的双极阵列和许多有丝分裂马达来协调姐妹染色单体的精确分离。在这里，我们讨论了最近的数学模型和计算机模拟，这些模型与实验研究相结合，有助于解释纺锤体机器执行其关键功能的分子机制。我们回顾了当前关于纺锤体组装、定位、维持和延长；染色体捕获和汇聚；以及纺锤体组装检查点的模型。我们讨论了将建模应用于有丝分裂其他方面的一些局限性，以及构建更全面的系统级模型的可行性。
