Faulkner Melissa Spezia, Chao Wei-Hsun, Kamath Savitri K, Quinn Laurie, Fritschi Cynthia, Maggiore Jack A, Williams Robert H, Reynolds Robert D
College of Nursing, University of Illinois at Chicago, Chicago, IL 60612, USA.
J Cardiovasc Nurs. 2006 Jan-Feb;21(1):47-55.
Limited research is available on the possible differences in the cardiovascular risk factors of total homocysteine (tHcy), dietary energy, and lipids among adolescents with type 1 diabetes mellitus (DM), type 2 DM, or healthy controls. This study's primary aim was to compare the dietary energy and the intake of macronutrients and micronutrients of folate, and vitamins B6 and B12, as well as lipids and tHcy for adolescents with type 1 DM, type 2 DM, and healthy non-DM controls.
This secondary analysis of the merging of 2 datasets included the following adolescents: 50 with type 1 DM, 14 with type 2 DM, and 53 controls. Mean ages for those with type 1 versus type 2 DM were 15.2 +/- 1.9 versus 16.1 +/- 1.9 years, respectively. Mean age for the controls was 16.5 +/- 1.0 years. Variables included fasting tHcy and lipids, and 24-hour dietary recalls for macronutrients and micronutrients. Hemoglobin A1c was obtained for those with DM. Statistical analyses included one-way analyses of variance, Pearson correlations, and stepwise regression.
Adolescents with type 1 DM had the lowest tHcy values (P <.05), which were reflective of the limited extant research with this population. Lipid profiles and dietary energy did not differ significantly among the 3 groups. Hemoglobin A1c was related to total cholesterol and triglycerides in those with type 1 DM, confirming the importance of promoting better metabolic control in lipid management for these youth. Future research should continue to explore the validity of tHcy and lipids as predictors of CV risks for youth with type 1 and type 2 DM.
关于1型糖尿病（DM）、2型DM青少年或健康对照者在总同型半胱氨酸（tHcy）、膳食能量和脂质等心血管危险因素方面可能存在的差异，现有研究有限。本研究的主要目的是比较1型DM、2型DM青少年以及健康非DM对照者的膳食能量、宏量营养素和微量营养素（叶酸、维生素B6和维生素B12）的摄入量，以及脂质和tHcy水平。
对两个数据集合并后的二次分析纳入了以下青少年：50例1型DM患者、14例2型DM患者和53例对照者。1型DM与2型DM患者的平均年龄分别为15.2±1.9岁和16.1±1.9岁。对照者的平均年龄为16.5±1.0岁。变量包括空腹tHcy和脂质，以及宏量营养素和微量营养素的24小时膳食回顾。对DM患者检测糖化血红蛋白。统计分析包括单因素方差分析、Pearson相关性分析和逐步回归分析。
1型DM青少年的tHcy值最低（P<.05），这与该人群现有有限研究结果相符。三组之间的脂质谱和膳食能量无显著差异。1型DM患者的糖化血红蛋白与总胆固醇和甘油三酯相关，这证实了在这些青少年的脂质管理中促进更好的代谢控制的重要性。未来的研究应继续探索tHcy和脂质作为1型和2型DM青少年心血管风险预测指标的有效性。
