Liang Meng, Zhou Yuan, Jiang Tianzi, Liu Zhening, Tian Lixia, Liu Haihong, Hao Yihui
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, PR China.
Neuroreport. 2006 Feb 6;17(2):209-13. doi: 10.1097/01.wnr.0000198434.06518.b8.
Using resting-state functional magnetic resonance imaging, we examined the functional connectivity throughout the entire brain in schizophrenia. The abnormalities in functional connectivity were identified by comparing the correlation coefficients of each pair of 116 brain regions between 15 patients and 15 controls. Then, the global distribution of the abnormal functional connectivities was examined. Experimental results indicated, in general, a decreased functional connectivity in schizophrenia during rest, and such abnormalities were widely distributed throughout the entire brain rather than restricted to a few specific brain regions. The results provide a quantitative support for the hypothesis that schizophrenia may arise from the disrupted functional integration of widespread brain areas.
我们使用静息态功能磁共振成像技术，研究了精神分裂症患者全脑的功能连接。通过比较15名患者和15名对照者之间116个脑区每对区域的相关系数，确定了功能连接的异常情况。然后，研究了异常功能连接的整体分布。实验结果表明，总体而言，精神分裂症患者在静息状态下功能连接降低，且这种异常广泛分布于全脑，而非局限于少数特定脑区。这些结果为精神分裂症可能源于广泛脑区功能整合受损这一假说提供了定量支持。
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