Pathmeswaran A, Kasturiratne A, Fonseka M, Nandasena S, Lalloo D G, de Silva H J
Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Trans R Soc Trop Med Hyg. 2006 Sep;100(9):874-8. doi: 10.1016/j.trstmh.2005.10.003. Epub 2006 Jan 18.
The outcome of snakebite is related to the biting species but it is often difficult to identify the biting snake, particularly in community settings. We have developed a clinical scoring system suitable for use in epidemiological surveys, with the main aim of identifying the presumed biting species in those with systemic envenoming who require treatment. The score took into account ten features relating to bites of the five medically important snakes in Sri Lanka, and an algorithm was developed applying different weightings for each feature for different species. A systematically developed artificial data set was used to fine tune the score and to develop criteria for definitive identification. The score was prospectively validated using 134 species-confirmed snakebites. It correctly differentiated the bites caused by the three snakes that commonly cause major clinical problems (Russell's viper (RV), kraits and cobra) from other snakes (hump-nosed viper (HNV) and saw-scaled viper (SSV)) with 80% sensitivity and 100% specificity. For individual species, sensitivity and specificity were, respectively: cobra 76%, 99%; kraits 85%, 99%; and RV 70%, 99%. As anticipated, the score was insensitive in the identification of bites due to HNV and SSV.
蛇咬伤的后果与咬人的蛇种有关,但通常很难确定咬人的蛇,尤其是在社区环境中。我们开发了一种适用于流行病学调查的临床评分系统,主要目的是在需要治疗的全身性中毒患者中识别可能咬人的蛇种。该评分考虑了与斯里兰卡五种具有医学重要性的蛇咬伤相关的十个特征,并针对不同蛇种为每个特征应用不同权重开发了一种算法。使用系统开发的人工数据集对评分进行微调,并制定明确识别的标准。该评分通过134例经物种确认的蛇咬伤进行了前瞻性验证。它以80%的敏感性和100%的特异性正确区分了三种通常会导致重大临床问题的蛇(罗素蝰蛇(RV)、金环蛇和眼镜蛇)与其他蛇(尖吻蝮(HNV)和锯鳞蝰蛇(SSV))造成的咬伤。对于单个蛇种,敏感性和特异性分别为:眼镜蛇76%,99%;金环蛇85%,99%;罗素蝰蛇70%,99%。正如预期的那样,该评分在识别尖吻蝮和锯鳞蝰蛇造成的咬伤方面不敏感。