Bussiere Joseph R, Beer Tomasz M, Neiss Michelle B, Janowsky Jeri S
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239-3098, USA.
Behav Neurosci. 2005 Dec;119(6):1429-37. doi: 10.1037/0735-7044.119.6.1429.
Androgen deprivation leads to a profound loss of synaptic density in the hippocampus and changes in learning and memory in animal models. The authors examined group differences in verbal memory between men on androgen deprivation therapy (ADT), a commonly used treatment for prostate cancer, and healthy men. The authors found that men on ADT have a specific impairment of retention but normal encoding and retrieval processes on a word list-learning task. Speed and accuracy for both perceptual and semantic encoding, as well as retrieval at a very short retention interval, were not affected; however, recognition fell to chance after a 2-min retention interval in men on ADT. Healthy men showed only moderate forgetting, and performance was still above chance at 12 min. This pattern of preserved encoding and retrieval but impaired retention suggests that androgens play a role in hippocampally mediated memory processes, possibly having a specific affect on consolidation.
雄激素剥夺会导致动物模型中海马体突触密度显著降低以及学习和记忆发生变化。作者研究了接受雄激素剥夺疗法（ADT，一种常用的前列腺癌治疗方法）的男性与健康男性在言语记忆方面的组间差异。作者发现，接受ADT治疗的男性在单词列表学习任务中存在特定的记忆保持障碍，但编码和提取过程正常。知觉和语义编码的速度与准确性，以及在非常短的记忆保持间隔后的提取，均未受到影响；然而，接受ADT治疗的男性在2分钟记忆保持间隔后，识别率降至随机水平。健康男性仅表现出适度的遗忘，且在12分钟时表现仍高于随机水平。这种编码和提取保存但记忆保持受损的模式表明，雄激素在海马体介导的记忆过程中发挥作用，可能对巩固过程有特定影响。
